Literature DB >> 17535270

Variation in 5' promoter region of the APOE gene contributes to predicting ischemic heart disease (IHD) in the population at large: the Copenhagen City Heart Study.

J H Stengård1, R Frikke-Schmidt, A Tybjaerg-Hansen, B G Nordestgaard, C F Sing.   

Abstract

The objective of this study was to evaluate whether an increased hazard of developing ischemic heart disease (IHD) is associated with any of the three genotypes A560T832/A560T832, A560T832/A560G832 and A560T832/T560T832, defined by variations in two non-coding SNPs in the 5' promoter region of the apolipoprotein E (APOE) gene. These genotypes were selected because they distinguished between high and low levels of HDL-C, TG and/or T-C in our earlier study of multiple samples defined by gender and population. We found a significant increase (p<0.05) in the hazard of IHD in females with the A560T832/T560T832 genotype that remained significant after fitting the effects of dyslipidemia, other established risk factors, and the structural isoform variations of the ApoE molecule. We discuss why this statistically significant genetic predictor may not be an appropriate screening test for IHD in the Danish population at large.

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Year:  2007        PMID： 17535270      PMCID： PMC2094107          DOI： 10.1111/j.1469-1809.2007.00370.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  45 in total

1.  A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation.

Authors:  M R Nelson; S L Kardia; R E Ferrell; C F Sing
Journal:  Genome Res       Date:  2001-03       Impact factor: 9.043

2.  Replication validity of genetic association studies.

Authors:  J P Ioannidis; E E Ntzani; T A Trikalinos; D G Contopoulos-Ioannidis
Journal:  Nat Genet       Date:  2001-11       Impact factor: 38.330

3.  Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations-the ECTIM study.

Authors:  J C Lambert; T Brousseau; V Defosse; A Evans; D Arveiler; J B Ruidavets; B Haas; J P Cambou; G Luc; P Ducimetière; F Cambien; M C Chartier-Harlin; P Amouyel
Journal:  Hum Mol Genet       Date:  2000-01-01       Impact factor: 6.150

4.  Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism.

Authors:  S M Fullerton; A G Clark; K M Weiss; D A Nickerson; S L Taylor; J H Stengârd; V Salomaa; E Vartiainen; M Perola; E Boerwinkle; C F Sing
Journal:  Am J Hum Genet       Date:  2000-09-13       Impact factor: 11.025

5.  Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene.

Authors:  D A Nickerson; S L Taylor; S M Fullerton; K M Weiss; A G Clark; J H Stengård; V Salomaa; E Boerwinkle; C F Sing
Journal:  Genome Res       Date:  2000-10       Impact factor: 9.043

6.  Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease.

Authors:  L Viitanen; J Pihlajamäki; R Miettinen; P Kärkkäinen; I Vauhkonen; P Halonen; A Kareinen; S Lehto; M Laakso
Journal:  J Mol Med (Berl)       Date:  2001-07-25       Impact factor: 4.599

7.  Context-dependent and invariant associations between lipids, lipoproteins, and apolipoproteins and apolipoprotein E genotype.

Authors:  R Frikke-Schmidt; B G Nordestgaard; B Agerholm-Larsen; P Schnohr; A Tybjaerg-Hansen
Journal:  J Lipid Res       Date:  2000-11       Impact factor: 5.922

8.  Subsets of SNPs define rare genotype classes that predict ischemic heart disease.

Authors:  Ruth Frikke-Schmidt; Charles F Sing; Børge G Nordestgaard; Rolf Steffensen; Anne Tybjaerg-Hansen
Journal:  Hum Genet       Date:  2006-09-28       Impact factor: 4.132

9.  Apolipoprotein E genotype: epsilon32 women are protected while epsilon43 and epsilon44 men are susceptible to ischemic heart disease: the Copenhagen City Heart Study.

Authors:  R Frikke-Schmidt; A Tybjaerg-Hansen; R Steffensen; G Jensen; B G Nordestgaard
Journal:  J Am Coll Cardiol       Date:  2000-04       Impact factor: 24.094

Review 10.  Apolipoprotein E: far more than a lipid transport protein.

Authors:  R W Mahley; S C Rall
Journal:  Annu Rev Genomics Hum Genet       Date:  2000       Impact factor: 8.929
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  6 in total

1.  Context-dependent associations between variation in risk of ischemic heart disease and variation in the 5' promoter region of the apolipoprotein E gene in Danish women.

Authors:  Jari H Stengård; Greg Dyson; Ruth Frikke-Schmidt; Anne Tybjaerg-Hansen; Borge G Nordestgaard; Charles F Sing
Journal:  Circ Cardiovasc Genet       Date:  2009-12-03

2.  Validated context-dependent associations of coronary heart disease risk with genotype variation in the chromosome 9p21 region: the Atherosclerosis Risk in Communities study.

Authors:  Christine M Lusk; Greg Dyson; Andrew G Clark; Christie M Ballantyne; Ruth Frikke-Schmidt; Anne Tybjærg-Hansen; Eric Boerwinkle; Charles F Sing
Journal:  Hum Genet       Date:  2014-06-03       Impact factor: 4.132

3.  Genetic influences on blood lipids and cardiovascular disease risk: tools for primary prevention.

Authors:  José M Ordovas
Journal:  Am J Clin Nutr       Date:  2009-04-01       Impact factor: 7.045

Review 4.  Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals.

Authors:  Tauseef A Khan; Tina Shah; David Prieto; Weili Zhang; Jackie Price; Gerald R Fowkes; Jackie Cooper; Philippa J Talmud; Steve E Humphries; Johan Sundstrom; Jaroslav A Hubacek; Shah Ebrahim; Debbie A Lawlor; Yoav Ben-Shlomo; Mohammad R Abdollahi; Arjen J C Slooter; Zoltan Szolnoki; Manjinder Sandhu; Nicholas Wareham; Ruth Frikke-Schmidt; Anne Tybjærg-Hansen; Gerda Fillenbaum; Bastiaan T Heijmans; Tomohiro Katsuya; Grazyna Gromadzka; Andrew Singleton; Luigi Ferrucci; John Hardy; Bradford Worrall; Stephen S Rich; Mar Matarin; John Whittaker; Tom R Gaunt; Peter Whincup; Richard Morris; John Deanfield; Ann Donald; George Davey Smith; Mika Kivimaki; Meena Kumari; Liam Smeeth; Kay-Tee Khaw; Michael Nalls; James Meschia; Kai Sun; Rutai Hui; Ian Day; Aroon D Hingorani; Juan P Casas
Journal:  Int J Epidemiol       Date:  2013-04       Impact factor: 7.196

Review 5.  Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review.

Authors:  Szilvia Fiatal; Róza Ádány
Journal:  Front Public Health       Date:  2018-01-31

6.  Effects of polymorphisms in APOA5 on the plasma levels of triglycerides and risk of coronary heart disease in Jilin, northeast China: a case-control study.

Authors:  Yueyue You; Yan-Hua Wu; Yangyu Zhang; Lili Zhang; Yan Song; Wei Bai; Yuanyuan Li; Yaqin Yu; Changgui Kou
Journal:  BMJ Open       Date:  2018-06-04       Impact factor: 2.692
  6 in total

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