INTRODUCTION: The authors report a case of three brothers. CASE DESCRIPTIONS: Two of these siblings presented with congenital growth hormone deficiency (GHD) and Chiari I malformation (CIM). The third younger brother has been found not to have GHD or the CIM. DISCUSSION: Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa (PF) has been determined to be altered in patients with CIM and GHD. CONCLUSION: Our current case reports strengthen the association between these two pathological entities and, to our knowledge, is the first description of both defects in siblings.
INTRODUCTION: The authors report a case of three brothers. CASE DESCRIPTIONS: Two of these siblings presented with congenital growth hormone deficiency (GHD) and Chiari I malformation (CIM). The third younger brother has been found not to have GHD or the CIM. DISCUSSION: Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa (PF) has been determined to be altered in patients with CIM and GHD. CONCLUSION: Our current case reports strengthen the association between these two pathological entities and, to our knowledge, is the first description of both defects in siblings.
Authors: R Shane Tubbs; John C Wellons; Matthew D Smyth; Alfred A Bartolucci; Jeffrey P Blount; W Jerry Oakes; Paul A Grabb Journal: Pediatr Neurosurg Date: 2003-06 Impact factor: 1.162
Authors: Juan F Martínez-Lage; Encarna Guillén-Navarro; Antonio L López-Guerrero; María José Almagro; Beatriz Cuartero-Pérez; Pedro de la Rosa Journal: Childs Nerv Syst Date: 2011-10-13 Impact factor: 1.475
Authors: Christina A Markunas; Karen Soldano; Kaitlyn Dunlap; Heidi Cope; Edgar Asiimwe; Jeffrey Stajich; David Enterline; Gerald Grant; Herbert Fuchs; Simon G Gregory; Allison E Ashley-Koch Journal: PLoS One Date: 2013-04-19 Impact factor: 3.240