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Literature DB >> 17533668

Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin.

Abstract

Phytohemagglutinin, an extract of the kidney bean, Phaseolus vulgaris, induces in human leukocyte cultures an inhibitor of the cytopathic effects of Sindbis virus. The physicochemical and biological properties of this virus-inhibitor are similar to those of interferon induced by Newcastle disease virus, except for an instability at pH 2 and 10 and at 56 degrees C.

Entities: Species

Keywords: INTERFERONS; LEUKOCYTES/drug effects; NEWCASTLE DISEASE VIRUS; PHYTOHEMAGGLUTININS/pharmacology; VIRUSES/drug effects

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Substances：

Year: 1965 PMID： 17533668

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

92 in total

1. The influence of physicochemical factors on the thermal inactivation of murine interferon.

Authors: R Jariwalla; S E Grossberg; J J Sedmak
Journal: Arch Virol Date: 1975 Impact factor: 2.574

2. Comparison of macrophage antimicrobial responses induced by type II interferons of the goldfish (Carassius auratus L.).

Authors: Leon Grayfer; Erick Garcia Garcia; Miodrag Belosevic
Journal: J Biol Chem Date: 2010-05-27 Impact factor: 5.157

3. Production and characterization of guinea pig recombinant gamma interferon and its effect on macrophage activation.

Authors: A Jeevan; C T McFarland; T Yoshimura; T Skwor; H Cho; T Lasco; D N McMurray
Journal: Infect Immun Date: 2006-01 Impact factor: 3.441

4. Various molecular species of interferon induced by viral and nonviral agents.

Authors: T C Merigan
Journal: Bacteriol Rev Date: 1967-06

5. The interaction of human macrophages and lymphocytes in the phytohemagglutinin-stimulated production of interferon.

Authors: L B Epstein; M J Cline; T C Merigan
Journal: J Clin Invest Date: 1971-04 Impact factor: 14.808

6. Inhibition of the mitogenic response of normal peripheral lymphocytes by extracts or supernatant fluids of a Herpesvirus saimiri lymphoid tumor cell line.

Authors: R H Neubauer; W C Wallen; H Rabin
Journal: Infect Immun Date: 1975-11 Impact factor: 3.441

Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin.

1. The influence of physicochemical factors on the thermal inactivation of murine interferon.

2. Comparison of macrophage antimicrobial responses induced by type II interferons of the goldfish (Carassius auratus L.).

3. Production and characterization of guinea pig recombinant gamma interferon and its effect on macrophage activation.

4. Various molecular species of interferon induced by viral and nonviral agents.

5. The interaction of human macrophages and lymphocytes in the phytohemagglutinin-stimulated production of interferon.

6. Inhibition of the mitogenic response of normal peripheral lymphocytes by extracts or supernatant fluids of a Herpesvirus saimiri lymphoid tumor cell line.

7. Differential expression of human interferon genes.

8. Rabbit macrophage interferons. II. Some physicochemical properties and estimations of molecular weights.

9. Gamma interferon inhibits production of Anti-OspA borreliacidal antibody in vitro.

10. Use of monoclonal antibodies as sensitive and specific probes for biologically active human gamma-interferon.