| Literature DB >> 17533131 |
Burkhardt Voigt1, Claudius Coburger, Joséf Monár, Andreas Hilgeroth.
Abstract
Series of novel N-acyloxy-1,4-dihydropyridines have been synthesized and evaluated as P-glycoprotein inhibitors in an in vitro assay to estimate their potential to act as multidrug resistance modulators in cancer cells. Structure-activity relationships are discussed and prove a significant and regiospecific influence of certain functional groups.Entities:
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Year: 2007 PMID： 17533131 DOI： 10.1016/j.bmc.2007.05.036
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641