OBJECTIVES: To analyse the effects of ranitidine treatment on vaccination induced antibody responses in patients with chronic lymphocytic leukaemia (CLL). METHODS: Fifty CLL patients were vaccinated with tetanus conjugated Hib vaccine and a 23-valent pneumococcal polysaccharide vaccine with (n = 25) or without (n = 25) ranitidine treatment in a matched case--control setting. Anti tetanus toxoid (TT), anti-Hib and anti-pneumococcal antibody levels were determined before and after vaccination. Additionally, cytokine levels were assessed in patients treated with ranitidine. RESULTS: Vaccination-induced increases in anti-Hib and anti-TT antibody levels were higher in the ranitidine group compared with the control group. Anti-pneumococcal antibody responses were not improved by administration of ranitidine. Higher levels of IL-18 were found in patients treated with ranitidine compared with healthy controls. Levels of IL-6, IL-8, IL-18, RANTES, IP-10, sVCAM-1 and sICAM-1 were within normal ranges and did not change during ranitidine treatment. CONCLUSION: Ranitidine treatment improves vaccination-induced T-cell dependent antibody responses in patients with CLL but has no beneficial effect on the response to vaccination with unconjugated polysaccharide antigens.
OBJECTIVES: To analyse the effects of ranitidine treatment on vaccination induced antibody responses in patients with chronic lymphocytic leukaemia (CLL). METHODS: Fifty CLL patients were vaccinated with tetanus conjugated Hib vaccine and a 23-valent pneumococcalpolysaccharide vaccine with (n = 25) or without (n = 25) ranitidine treatment in a matched case--control setting. Anti tetanus toxoid (TT), anti-Hib and anti-pneumococcal antibody levels were determined before and after vaccination. Additionally, cytokine levels were assessed in patients treated with ranitidine. RESULTS: Vaccination-induced increases in anti-Hib and anti-TT antibody levels were higher in the ranitidine group compared with the control group. Anti-pneumococcal antibody responses were not improved by administration of ranitidine. Higher levels of IL-18 were found in patients treated with ranitidine compared with healthy controls. Levels of IL-6, IL-8, IL-18, RANTES, IP-10, sVCAM-1 and sICAM-1 were within normal ranges and did not change during ranitidine treatment. CONCLUSION:Ranitidine treatment improves vaccination-induced T-cell dependent antibody responses in patients with CLL but has no beneficial effect on the response to vaccination with unconjugated polysaccharide antigens.
Authors: Rosa Lapalombella; Leslie Andritsos; Qing Liu; Sarah E May; Rebekah Browning; Lan V Pham; Kristie A Blum; William Blum; Asha Ramanunni; Chelsey A Raymond; Lisa L Smith; Amy Lehman; Xiaokui Mo; David Jarjoura; Ching-Shih Chen; Richard Ford; Christoph Rader; Natarajan Muthusamy; Amy J Johnson; John C Byrd Journal: Blood Date: 2009-11-24 Impact factor: 22.113