Literature DB >> 17532631

Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.

Ronghui Lin1, Peter J Connolly, Yanhua Lu, George Chiu, Shengjian Li, Yang Yu, Shenlin Huang, Xun Li, Stuart L Emanuel, Steven A Middleton, Robert H Gruninger, Mary Adams, Angel R Fuentes-Pesquera, Lee M Greenberger.   

Abstract

A series of 3,5-disubstituted pyrazolo[3,4-b]pyridine cyclin-dependent kinase (CDK) inhibitors was synthesized. These compounds showed potent and selective CDK inhibitory activities and inhibited in vitro cellular proliferation in cultured human tumor cells. Selected compounds were evaluated in an in vivo tumor xenograft model. The synthesis and biological evaluation of these pyrazolo[3,4-b]pyridines and related compounds are reported.

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Year:  2007        PMID： 17532631     DOI： 10.1016/j.bmcl.2007.05.029

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Construction of pyrazolo[3,4-b]pyridines and pyrazolo[4,3-c]pyridines by ring closure of 3-acylpyridine N-oxide tosylhydrazones.

Authors:  William J Lominac; Megan L D'Angelo; Mark D Smith; Darius A Ollison; James M Hanna
Journal:  Tetrahedron Lett       Date:  2012-02-22       Impact factor: 2.415

2.  Reactivity of pyrazole derivatives with halomethanes: A DFT theoretical study.

Authors:  Monia Chebbi; Youssef Arfaoui
Journal:  J Mol Model       Date:  2018-07-09       Impact factor: 1.810

3.  Organometallic 3-(1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines as potential anticancer agents.

Authors:  Iryna N Stepanenko; Maria S Novak; Gerhard Mühlgassner; Alexander Roller; Michaela Hejl; Vladimir B Arion; Michael A Jakupec; Bernhard K Keppler
Journal:  Inorg Chem       Date:  2011-10-27       Impact factor: 5.165

4.  Design and Synthesis of New Substituted Pyrazolopyridines with Potent Antiproliferative Activity.

Authors:  Vassiliki Giannouli; Nikolaos Lougiakis; Ioannis K Kostakis; Nicole Pouli; Panagiotis Marakos; Alexios-Leandros Skaltsounis; David A Horne; Sangkil Nam; Katerina Gioti; Roxane Tenta
Journal:  Med Chem       Date:  2020       Impact factor: 2.329

5.  Four-component bicyclization approaches to skeletally diverse pyrazolo[3,4-b]pyridine derivatives.

Authors:  Xing-Jun Tu; Wen-Juan Hao; Qin Ye; Shuang-Shuang Wang; Bo Jiang; Guigen Li; Shu-Jiang Tu
Journal:  J Org Chem       Date:  2014-11-04       Impact factor: 4.354

6.  "On Water" Palladium Catalyzed Direct Arylation of 1H-Indazole and 1H-7-Azaindazole.

Authors:  Khadija Gambouz; Abdelmoula El Abbouchi; Sarah Nassiri; Franck Suzenet; Mostapha Bousmina; Mohamed Akssira; Gérald Guillaumet; Saïd El Kazzouli
Journal:  Molecules       Date:  2020-06-18       Impact factor: 4.411

Review 7.  1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications.

Authors:  Ana Donaire-Arias; Ana Maria Montagut; Raimon Puig de la Bellacasa; Roger Estrada-Tejedor; Jordi Teixidó; José I Borrell
Journal:  Molecules       Date:  2022-03-30       Impact factor: 4.411

8.  Ionic liquid-promoted multi-component reaction: novel and efficient preparation of pyrazolo[3,4-b]pyridinone, pyrazolo[3,4-b]-quinolinone and their hybrids with pyrimidine nucleoside.

Authors:  Xinying Zhang; Dongfang Li; Xuesen Fan; Xia Wang; Xiaoyan Li; Guirong Qu; Jianji Wang
Journal:  Mol Divers       Date:  2009-06-12       Impact factor: 3.364

9.  Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity.

Authors:  Adel A-H Abdel-Rahman; Amira K F Shaban; Ibrahim F Nassar; Dina S El-Kady; Nasser S M Ismail; Samy F Mahmoud; Hanem M Awad; Wael A El-Sayed
Journal:  Molecules       Date:  2021-06-26       Impact factor: 4.411
  9 in total

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