Literature DB >> 17532532

Emerging trends in the therapy of COPD: bronchodilators as mono- and combination therapies.

Mary F Fitzgerald1, J Craig Fox.   

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease that is characterized by progressive airway obstruction that, unlike asthma, is relatively insensitive to bronchodilators and to the classic anti-inflammatory therapy, corticosteroids. In this review we consider the potential of bronchodilator drugs and corticosteroid drugs that are in clinical development for COPD and discuss how the best treatments might be achieved with combinations of drugs that are either already launched or close to launch.

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Year:  2007        PMID: 17532532     DOI: 10.1016/j.drudis.2007.04.003

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  5 in total

1.  The β2-subtype of adrenoceptors mediates inhibition of pro-fibrotic events in human lung fibroblasts.

Authors:  F Lamyel; M Warnken-Uhlich; W K Seemann; K Mohr; E Kostenis; A S Ahmedat; M Smit; R Gosens; H Meurs; A Miller-Larsson; Kurt Racké
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2011-05-21       Impact factor: 3.000

2.  Disability Retirement After First Admission with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Danish Nationwide Registry Cohort Study Using a Retrospective Follow-Up Design.

Authors:  Peter Ascanius Jacobsen; Kristian Kragholm; Christian Torp-Pedersen; Ulla Møller Weinreich
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2022-10-11

Review 3.  Pulmonary fibroblasts, an emerging target for anti-obstructive drugs.

Authors:  Kurt Racké; Susanne Haag; Amit Bahulayan; Mareille Warnken
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-02-13       Impact factor: 3.000

Review 4.  Novel long-acting bronchodilators for COPD and asthma.

Authors:  M Cazzola; M G Matera
Journal:  Br J Pharmacol       Date:  2008-07-07       Impact factor: 8.739

5.  Dual regulation of β2-adrenoceptor messenger RNA expression in human lung fibroblasts by β2-cAMP signaling; delayed upregulated inhibitors oppose a rapid in onset, direct stimulation of gene expression.

Authors:  N Kämpfer; F Lamyel; I Schütz; M Warnken; K Hoffmann; I von Kügelgen; Kurt Racké
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2014-04-08       Impact factor: 3.000

  5 in total

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