| Literature DB >> 17531479 |
Hiroyuki Kai1, Yasuhide Morioka, Minoru Tomida, Tadashi Takahashi, Maki Hattori, Kohji Hanasaki, Katsumi Koike, Hiroki Chiba, Shunji Shinohara, Toshiyuki Kanemasa, Yuka Iwamoto, Kohji Takahashi, Yoshitaka Yamaguchi, Takahiko Baba, Takayoshi Yoshikawa, Hideyuki Takenaka.
Abstract
Structure-activity relationships and efforts to optimize the pharmacokinetic profile of a class of 2-arylimino-5,6-dihydro-4H-1,3-thiazines as cannabinoid receptor agonists are described. Among the compounds examined, compound 14 showed potent affinity and high selectivity for CB2, and compound 23 showed potent affinities against CB1 and CB2. These compounds displayed oral bioavailability.Entities:
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Year: 2007 PMID： 17531479 DOI： 10.1016/j.bmcl.2007.04.099
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823