| Literature DB >> 17530896 |
Cyrille Sabot1, Kanduluru Ananda Kumar, Cyril Antheaume, Charles Mioskowski.
Abstract
We describe the first effective H/D exchange reaction with acidic substrates in CDCl(3) at room temperature. The particularly mild reaction conditions involved (solvent, base, and temperature) allow the chemoselective deuteration of ketones over esters. An NMR study was conducted with the aim of rationalizing the results obtained in the presence of TBD as catalyst.Entities:
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Year: 2007 PMID： 17530896 DOI： 10.1021/jo070307h
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354