Literature DB >> 17530855

Addition of difluoromethyl radicals to glycals: a new route to alpha-CF2-D-glycosides.

Benjamin Moreno1, Cindy Quehen, Maureen Rose-Hélène, Eric Leclerc, Jean-Charles Quirion.   

Abstract

The synthesis of synthetically useful alpha-CF2-glycosides by radical addition of ethyl bromodifluoroacetate onto 2-benzyloxyglycals is described. The methodology provides an access to alpha-O-glycoside mimics and, potentially, to valuable alpha-O-glycoconjugate analogues.

Entities:  

Year:  2007        PMID: 17530855     DOI: 10.1021/ol070835f

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

Review 1.  Bioisosteres of Carbohydrate Functional Groups in Glycomimetic Design.

Authors:  Rachel Hevey
Journal:  Biomimetics (Basel)       Date:  2019-07-28

2.  Design and efficient synthesis of pyrazoline and isoxazole bridged indole C-glycoside hybrids as potential anticancer agents.

Authors:  Priti Kumari; Vishnu S Mishra; Chintam Narayana; Ashish Khanna; Anindita Chakrabarty; Ram Sagar
Journal:  Sci Rep       Date:  2020-04-20       Impact factor: 4.379

  2 in total

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