Literature DB >> 17529972

Improved antimicrobial peptides based on acyl-lysine oligomers.

Inna S Radzishevsky1, Shahar Rotem, Dmitry Bourdetsky, Shiri Navon-Venezia, Yehuda Carmeli, Amram Mor.   

Abstract

We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.

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Year:  2007        PMID： 17529972     DOI： 10.1038/nbt1309

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


  68 in total

Review 1.  Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold.

Authors:  Brandon Findlay; George G Zhanel; Frank Schweizer
Journal:  Antimicrob Agents Chemother       Date:  2010-08-09       Impact factor: 5.191

2.  Experimental conditions that enhance potency of an antibacterial oligo-acyl-lysyl.

Authors:  Yair Goldfeder; Fadia Zaknoon; Amram Mor
Journal:  Antimicrob Agents Chemother       Date:  2010-04-12       Impact factor: 5.191

3.  Mechanisms mediating bactericidal properties and conditions that enhance the potency of a broad-spectrum oligo-acyl-lysyl.

Authors:  Hadar Sarig; Yair Goldfeder; Shahar Rotem; Amram Mor
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

Review 4.  Nontraditional therapies to treat Helicobacter pylori infection.

Authors:  Morris O Makobongo; Jeremy J Gilbreath; D Scott Merrell
Journal:  J Microbiol       Date:  2014-03-29       Impact factor: 3.422

5.  Synergy with rifampin and kanamycin enhances potency, kill kinetics, and selectivity of de novo-designed antimicrobial peptides.

Authors:  Aparna Anantharaman; Meryam Sardar Rizvi; Dinkar Sahal
Journal:  Antimicrob Agents Chemother       Date:  2010-02-22       Impact factor: 5.191

6.  Ultrashort peptide bioconjugates are exclusively antifungal agents and synergize with cyclodextrin and amphotericin B.

Authors:  Christopher J Arnusch; Hannah Ulm; Michaele Josten; Yana Shadkchan; Nir Osherov; Hans-Georg Sahl; Yechiel Shai
Journal:  Antimicrob Agents Chemother       Date:  2011-10-17       Impact factor: 5.191

7.  The oligo-acyl lysyl antimicrobial peptide C₁₂K-2β₁₂ exhibits a dual mechanism of action and demonstrates strong in vivo efficacy against Helicobacter pylori.

Authors:  Morris O Makobongo; Hanan Gancz; Beth M Carpenter; Dennis P McDaniel; D Scott Merrell
Journal:  Antimicrob Agents Chemother       Date:  2011-11-07       Impact factor: 5.191

8.  Underlying mechanism of in vivo and in vitro activity of C-terminal-amidated thanatin against clinical isolates of extended-spectrum beta-lactamase-producing Escherichia coli.

Authors:  Zheng Hou; Jun Lu; Chao Fang; Ying Zhou; Hui Bai; Xiaogong Zhang; Xiaoyan Xue; Yingying Chen; Xiaoxing Luo
Journal:  J Infect Dis       Date:  2010-12-09       Impact factor: 5.226

9.  Role of the conformational rigidity in the design of biomimetic antimicrobial compounds.

Authors:  Andrey Ivankin; Liran Livne; Amram Mor; Gregory A Caputo; William F Degrado; Mati Meron; Binhua Lin; David Gidalevitz
Journal:  Angew Chem Int Ed Engl       Date:  2010-11-02       Impact factor: 15.336

Review 10.  De novo designed synthetic mimics of antimicrobial peptides.

Authors:  Richard W Scott; William F DeGrado; Gregory N Tew
Journal:  Curr Opin Biotechnol       Date:  2008-11-17       Impact factor: 9.740
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