PURPOSE: To describe the presentation and treatment of a case of autoimmune polyglandular syndrome type 1 (APS1)-associated keratopathy and to review the associated literature. METHODS: A 23-year-old man with decreased vision secondary to APS1-associated keratopathy was treated with systemic immunosuppression and keratolimbal allograft (KLAL) stem cell transplantation. RESULTS: The patient maintains excellent vision 27 months after KLAL and systemic immunosuppression. CONCLUSIONS: An underlying etiology of APS1-associated keratopathy is stem cell deficiency, which can be treated effectively with KLAL and systemic immunosuppression.
PURPOSE: To describe the presentation and treatment of a case of autoimmune polyglandular syndrome type 1 (APS1)-associated keratopathy and to review the associated literature. METHODS: A 23-year-old man with decreased vision secondary to APS1-associated keratopathy was treated with systemic immunosuppression and keratolimbal allograft (KLAL) stem cell transplantation. RESULTS: The patient maintains excellent vision 27 months after KLAL and systemic immunosuppression. CONCLUSIONS: An underlying etiology of APS1-associated keratopathy is stem cell deficiency, which can be treated effectively with KLAL and systemic immunosuppression.
Authors: K Nagamine; P Peterson; H S Scott; J Kudoh; S Minoshima; M Heino; K J Krohn; M D Lalioti; P E Mullis; S E Antonarakis; K Kawasaki; S Asakawa; F Ito; N Shimizu Journal: Nat Genet Date: 1997-12 Impact factor: 38.330
Authors: S H Pearce; T Cheetham; H Imrie; B Vaidya; N D Barnes; R W Bilous; D Carr; K Meeran; N J Shaw; C S Smith; A D Toft; G Williams; P Kendall-Taylor Journal: Am J Hum Genet Date: 1998-12 Impact factor: 11.025
Authors: S Yeh; C S de Paiva; C S Hwang; K Trinca; A Lingappan; J K Rafati; W J Farley; D-Q Li; S C Pflugfelder Journal: Br J Ophthalmol Date: 2009-05-07 Impact factor: 4.638