Abraham Koshy1, Mary Jeyakumari. 1. Department of Gastroenterology, Institute of Population Health and Clinical Research, St. John's Medical College Hospital, Bangalore, India. koshyabe@yahoo.com
Abstract
BACKGROUND: In the majority of the cases of portal vein thrombosis in India, the etiology cannot be determined. A high level of factor VIII (FVIII) is a risk factor for venous thromboembolism. METHODS: In this study from South India, FVIII was estimated in 32 patients with idiopathic portal vein thrombosis (PVT), 12 healthy controls and 12 disease controls with chronic liver disease. RESULTS: Eighty-four percent of the patients with portal vein thrombosis (27/32) vs 17% of healthy controls (2/12) had high factor VIII levels (P <.0001). FVIII levels were significantly different between the subset of PVT patients with normal liver function compared with healthy controls (P <.001) and also between the subset of PVT patients with abnormal liver function compared with disease controls (P <.05). CONCLUSIONS: A high factor VIII level seems to contribute to the development of portal vein thrombosis in India.
BACKGROUND: In the majority of the cases of portal vein thrombosis in India, the etiology cannot be determined. A high level of factor VIII (FVIII) is a risk factor for venous thromboembolism. METHODS: In this study from South India, FVIII was estimated in 32 patients with idiopathic portal vein thrombosis (PVT), 12 healthy controls and 12 disease controls with chronic liver disease. RESULTS: Eighty-four percent of the patients with portal vein thrombosis (27/32) vs 17% of healthy controls (2/12) had high factor VIII levels (P <.0001). FVIII levels were significantly different between the subset of PVT patients with normal liver function compared with healthy controls (P <.001) and also between the subset of PVT patients with abnormal liver function compared with disease controls (P <.05). CONCLUSIONS: A high factor VIII level seems to contribute to the development of portal vein thrombosis in India.
Authors: Jose A Gómez-Puerta; Pilar Peris; Joan Carles Reverter; Gerard Espinosa; Angeles Martinez-Ferrer; Ana Monegal; Juan Monteagudo; Dolors Tàssies; Nuria Guañabens Journal: Medicine (Baltimore) Date: 2013-11 Impact factor: 1.889