Literature DB >> 17524640

Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.

Naohisa Ogo1, Shinya Oishi, Kenji Matsuno, Jun-ichi Sawada, Nobutaka Fujii, Akira Asai.   

Abstract

Inhibition of Eg5 represents a novel approach for the treatment of cancer. Here, we report the synthesis and structure-activity relationship of S-trityl-L-cysteine (STLC) derivatives as Eg5 inhibitors. Some of these derivatives such as 4f demonstrated enhanced inhibitory activity against Eg5 and induced mitotic arrest with characteristic monoastral spindles in HeLa cells.

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Year:  2007        PMID： 17524640     DOI： 10.1016/j.bmcl.2007.04.101

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Structure-Guided Design of Novel l-Cysteine Derivatives as Potent KSP Inhibitors.

Authors:  Naohisa Ogo; Yoshinobu Ishikawa; Jun-Ichi Sawada; Kenji Matsuno; Akihiro Hashimoto; Akira Asai
Journal:  ACS Med Chem Lett       Date:  2015-07-22       Impact factor: 4.345

2.  A potent chemotherapeutic strategy in prostate cancer: S-(methoxytrityl)-L-cysteine, a novel Eg5 inhibitor.

Authors:  Nai-Dong Xing; Sen-Tai Ding; Ryoichi Saito; Koji Nishizawa; Takashi Kobayashi; Takahiro Inoue; Shinya Oishi; Nobutaka Fujii; Jia-Jv Lv; Osamu Ogawa; Hiroyuki Nishiyama
Journal:  Asian J Androl       Date:  2011-02-07       Impact factor: 3.285

3.  A good molecular target for prostate cancer chemotherapy.

Authors:  Sidney R Grimes
Journal:  Asian J Androl       Date:  2011-02-14       Impact factor: 3.285

4.  Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.

Authors:  Delany Rodriguez; Chinnasamy Ramesh; Lauren H Henson; Lori Wilmeth; Bj K Bryant; Samuel Kadavakollu; Rebecca Hirsch; Johnelle Montoya; Porsha R Howell; Jon M George; David Alexander; Dennis L Johnson; Jeffrey B Arterburn; Charles B Shuster
Journal:  Bioorg Med Chem       Date:  2011-07-30       Impact factor: 3.641

5.  Design and synthesis of a new class of membrane-permeable triazaborolopyridinium fluorescent probes.

Authors:  Sudath Hapuarachchige; Gilbert Montaño; Chinnasamy Ramesh; Delany Rodriguez; Lauren H Henson; Casey C Williams; Samuel Kadavakkollu; Dennis L Johnson; Charles B Shuster; Jeffrey B Arterburn
Journal:  J Am Chem Soc       Date:  2011-04-07       Impact factor: 15.419

6.  Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.

Authors:  Fang Wang; James A D Good; Oliver Rath; Hung Yi Kristal Kaan; Oliver B Sutcliffe; Simon P Mackay; Frank Kozielski
Journal:  J Med Chem       Date:  2012-02-13       Impact factor: 7.446

7.  Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint.

Authors:  Banafsheh Etemad; Timo E F Kuijt; Geert J P L Kops
Journal:  Nat Commun       Date:  2015-12-01       Impact factor: 14.919

8.  Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells.

Authors:  Eric C Tauchman; Frederick J Boehm; Jennifer G DeLuca
Journal:  Nat Commun       Date:  2015-12-01       Impact factor: 14.919

9.  Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

Authors:  James A D Good; Fang Wang; Oliver Rath; Hung Yi Kristal Kaan; Sandeep K Talapatra; Dawid Podgórski; Simon P MacKay; Frank Kozielski
Journal:  J Med Chem       Date:  2013-02-27       Impact factor: 7.446

Review 10.  Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy.

Authors:  Stephanie M Myers; Ian Collins
Journal:  Future Med Chem       Date:  2016-03-15       Impact factor: 3.808
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