Literature DB >> 17524639

Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.

Rui Zhang1, Aihua Wang, Alan DeAngelis, Patricia Pelton, Jun Xu, Peifang Zhu, Lubing Zhou, Keith Demarest, William V Murray, Gee-Hong Kuo.   

Abstract

A novel series of potent and selective PPARdelta agonists, para-alkylthiophenoxyacetic acids, was identified. The synthesis and structure-activity relationships are described.

Entities:  

Mesh:

Substances:

Year:  2007        PMID: 17524639     DOI: 10.1016/j.bmcl.2007.05.007

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice.

Authors:  Fahrettin Haczeyni; Hans Wang; Vanessa Barn; Auvro R Mridha; Matthew M Yeh; W Geoffrey Haigh; George N Ioannou; Yun-Jung Choi; Charles A McWherter; Narcissus C-H Teoh; Geoffrey C Farrell
Journal:  Hepatol Commun       Date:  2017-07-31
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.