Literature DB >> 17524485

Curcumin and cyclopalladated complexes: a recipe for bifunctional biomaterials.

Daniela Pucci1, Rossana Bloise, Anna Bellusci, Sergio Bernardini, Mauro Ghedini, Sante Pirillo, Alessandra Valentini, Alessandra Crispini.   

Abstract

The first examples of binuclear and mononuclear ortho-palladated complexes based on a functionalized 2-phenylquinoline ligand have been synthesized and fully characterized. Conjugating cyclopalladated fragments to curcumin family biologically active beta-diketones gives in one single molecule two different functionalities. The structural variations based on the curcuminoid structure have been tested for their in vitro cytotoxic activity. The activity of complexes comprised of a cyclopalladated fragment conjugated to functionalized bioactive ligands, represents the potential of organometallic systems in generating new bifunctional biomaterials.

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Year:  2007        PMID： 17524485     DOI： 10.1016/j.jinorgbio.2007.03.006

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


  5 in total

1.  Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand as Potential Anticancer Agents.

Authors:  Monica Carreira; Rubén Calvo-Sanjuán; Mercedes Sanaú; Isabel Marzo; María Contel
Journal:  Organometallics       Date:  2012-07-25       Impact factor: 3.876

2.  Novel Palladium(II) Complexes that Influence Prominin-1/CD133 Expression and Stem Cell Factor Release in Tumor Cells.

Authors:  Eva Fischer-Fodor; Roman Mikláš; Lucia Rišiaňová; Mihai Cenariu; Ioana-Georgeta Grosu; Piroska Virag; Maria Perde-Schrepler; Ciprian Tomuleasa; Ioana Berindan-Neagoe; Ferdinand Devínsky; Natalia Miklášová
Journal:  Molecules       Date:  2017-03-30       Impact factor: 4.411

3.  A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells.

Authors:  Alessia Garufi; Daniela Trisciuoglio; Manuela Porru; Carlo Leonetti; Antonella Stoppacciaro; Valerio D'Orazi; Maria Avantaggiati; Alessandra Crispini; Daniela Pucci; Gabriella D'Orazi
Journal:  J Exp Clin Cancer Res       Date:  2013-10-07

4.  Organoruthenium(II) Complexes Ameliorates Oxidative Stress and Impedes the Age Associated Deterioration in Caenorhabditis elegans through JNK-1/DAF-16 Signalling.

Authors:  G Devagi; A Mohankumar; G Shanmugam; S Nivitha; F Dallemer; P Kalaivani; P Sundararaj; R Prabhakaran
Journal:  Sci Rep       Date:  2018-05-16       Impact factor: 4.379

5.  Evaluation of Antiproliferative Palladium(II) Complexes of Synthetic Bisdemethoxycurcumin towards In Vitro Cytotoxicity and Molecular Docking on DNA Sequence.

Authors:  Natalia Miklášová; Peter Herich; Juan Carlos Dávila-Becerril; Joaquín Barroso-Flores; Eva Fischer-Fodor; Jindra Valentová; Janka Leskovská; Jozef Kožíšek; Peter Takáč; Ján Mojžiš
Journal:  Molecules       Date:  2021-07-20       Impact factor: 4.411
  5 in total

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