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Literature DB >> 1752398

A case of HBs antigen negative fulminant hepatitis with IgM antibody to hepatitis B core antigen persisting more than seven years.

M Suga¹, K Shibata, T Kodama, K Arima, S Yamada, A Yachi.

Abstract

A 33-year old dentist developed fulminant hepatitis. At admission, a test for IgM antibody to hepatitis B core antigen (IgM anti-HBc) was positive, while tests for HBsAg and HBeAg were negative. He was cured of the disease, but in follow-up examinations from 1983 to 1990 IgM anti-HBc was continuously detected with radioimmunoassay while HBsAg and HBV-DNA were absent in the serum. However, HBcAg was found in a biopsied liver specimen and a small quantity of HBV-DNA was detectable by polymerase chain reaction assay. These observation suggest that the continuous detection of IgM anti-HBc without HBsAg in serum is due to persistent HBV infection and HBV replication in the liver.

Entities: Disease Gene

Mesh：

Substances：

Year: 1991 PMID： 1752398 DOI： 10.1007/bf02781685

Source DB: PubMed Journal: Gastroenterol Jpn ISSN： 0435-1339

13 in total

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Authors: Q L Choo; G Kuo; A J Weiner; L R Overby; D W Bradley; M Houghton
Journal: Science Date: 1989-04-21 Impact factor: 47.728

2. IgM-anti-HBc as a marker of persistent and IgG-anti-HBc as a marker of past hepatitis B infection. A longitudinal study over 5 years.

Authors: P Niermeiier; C H Gips; J R Huizenga; J Ringers; S Verkerk; H J Houthuff; B Houwen; J A Snijder; J O Nielsen
Journal: Acta Hepatogastroenterol (Stuttg) Date: 1978-10

3. Treatment of hepatic coma by exchange blood transfusion.

Authors: C Trey; D G Burns; S J Saunders
Journal: N Engl J Med Date: 1966-03-03 Impact factor: 91.245

4. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis.

Authors: H J Alter; R H Purcell; J W Shih; J C Melpolder; M Houghton; Q L Choo; G Kuo
Journal: N Engl J Med Date: 1989-11-30 Impact factor: 91.245

5. Immunoglobulin M antibody against hepatitis B core antigen for the diagnosis of fulminant type B hepatitis.

Authors: M Shimizu; M Ohyama; Y Takahashi; K Udo; M Kojima; M Kametani; F Tsuda; E Takai; Y Miyakawa; M Mayumi
Journal: Gastroenterology Date: 1983-03 Impact factor: 22.682

6. IgM antibody to hepatitis B core antigen in children with chronic type B hepatitis.

Authors: F Bortolotti; A Bertaggia; L Rude; M Armigliato; C Crivellaro; A Alberti; E Pornaro; G Realdi
Journal: Eur J Pediatr Date: 1987-07 Impact factor: 3.183

7. Diagnosis of acute and inapparent hepatitis B virus infections by measurement of IgM antibody to hepatitis B core antigen.

Authors: W H Gerlich; W Lüer; R Thomssen
Journal: J Infect Dis Date: 1980-07 Impact factor: 5.226

A case of HBs antigen negative fulminant hepatitis with IgM antibody to hepatitis B core antigen persisting more than seven years.

1. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.

2. IgM-anti-HBc as a marker of persistent and IgG-anti-HBc as a marker of past hepatitis B infection. A longitudinal study over 5 years.

3. Treatment of hepatic coma by exchange blood transfusion.

4. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis.

5. Immunoglobulin M antibody against hepatitis B core antigen for the diagnosis of fulminant type B hepatitis.

6. IgM antibody to hepatitis B core antigen in children with chronic type B hepatitis.

7. Diagnosis of acute and inapparent hepatitis B virus infections by measurement of IgM antibody to hepatitis B core antigen.

8. DNA polymerase associated with human hepatitis B antigen.

9. Immunoglobulin M antibody to hepatitis B core antigen in patients with chronic type B hepatitis.

10. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis.

1. Interruption of HBV intrauterine transmission: a clinical study.

2. Effect of hepatitis B immunoglobulin on interruption of HBV intrauterine infection.