Literature DB >> 17523654

Highly enantioselective Friedel-Crafts alkylations of indoles with simple enones catalyzed by zirconium(IV)-BINOL complexes.

Gonzalo Blay1, Isabel Fernández, José R Pedro, Carlos Vila.   

Abstract

Complexes of BINOL-based ligands with Zr(OtBu)4 catalyze the Friedel-Crafts alkylation reaction of indoles and pyrrole with nonchelating beta-substituted alpha,beta-enones at room temperature affording the expected products with good yields and ee above 95% in most of the studied examples.

Entities:  

Year:  2007        PMID： 17523654     DOI： 10.1021/ol0710820

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

Review 1.  DNA-encoded libraries (DELs): a review of on-DNA chemistries and their output.

Authors:  Ying Shi; Yan-Ran Wu; Jian-Qiang Yu; Wan-Nian Zhang; Chun-Lin Zhuang
Journal:  RSC Adv       Date:  2021-01-19       Impact factor: 3.361

2.  Conjugate addition of indoles to alpha,beta-unsaturated ketones using a Brønsted acid ionic liquid as an efficient catalyst.

Authors:  Chuan-Ji Yu; Chen-Jiang Liu
Journal:  Molecules       Date:  2009-08-27       Impact factor: 4.411

3.  Asymmetric Friedel-Crafts alkylation of indole with chalcones catalyzed by chiral phosphoric acids.

Authors:  Arrigo Scettri; Rosaria Villano; Maria Rosaria Acocella
Journal:  Molecules       Date:  2009-08-13       Impact factor: 4.411
  3 in total

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