AIM: To assess the incidence of late post-traumatic epilepsy (PTE) in patients with very severe traumatic brain injury (TBI) who either received or did not receive anti-epileptic prophylactic treatment. METHODS: Two populations were studied: 55 patients retrospectively and 82 subjects prospectively. RESULTS: Ten patients (18%) in the first population showed late PTE. Although the incidence was lower in patients who did not receive prophylactic treatment, the difference between the treated and the non-treated group was not statistically significant. Sixty-nine patients in the second group (84%) had prophylactic treatment. Twenty-seven patients (39%) suffered from late PTE during the 2-year follow-up period and 17 of them (63%) showed EEG epileptic abnormalities. No patient who did not receive preventive therapy suffered from late PTE during the observation period. CONCLUSIONS: Due to the negative cognitive effects of anti-epileptic drugs, the preliminary results are of considerable interest for the rehabilitation of patients with very severe TBI.
AIM: To assess the incidence of late post-traumatic epilepsy (PTE) in patients with very severe traumatic brain injury (TBI) who either received or did not receive anti-epileptic prophylactic treatment. METHODS: Two populations were studied: 55 patients retrospectively and 82 subjects prospectively. RESULTS: Ten patients (18%) in the first population showed late PTE. Although the incidence was lower in patients who did not receive prophylactic treatment, the difference between the treated and the non-treated group was not statistically significant. Sixty-nine patients in the second group (84%) had prophylactic treatment. Twenty-seven patients (39%) suffered from late PTE during the 2-year follow-up period and 17 of them (63%) showed EEG epileptic abnormalities. No patient who did not receive preventive therapy suffered from late PTE during the observation period. CONCLUSIONS: Due to the negative cognitive effects of anti-epileptic drugs, the preliminary results are of considerable interest for the rehabilitation of patients with very severe TBI.
Authors: Matthew L Diamond; Anne C Ritter; Michelle D Failla; Jennifer A Boles; Yvette P Conley; Patrick M Kochanek; Amy K Wagner Journal: Epilepsia Date: 2014-04-22 Impact factor: 5.864
Authors: Eric Azabou; Eric Magalhaes; Antoine Braconnier; Lyria Yahiaoui; Guy Moneger; Nicholas Heming; Djillali Annane; Jean Mantz; Fabrice Chrétien; Marie-Christine Durand; Frédéric Lofaso; Raphael Porcher; Tarek Sharshar Journal: PLoS One Date: 2015-10-08 Impact factor: 3.240
Authors: Batool F Kirmani; Diana Mungall Robinson; Ekokobe Fonkem; Kevin Graf; Jason H Huang Journal: Front Neurol Date: 2016-03-22 Impact factor: 4.003