INTRODUCTION: Infective endocarditis can lead to serious neurological complications including ischemic stroke and intracranial hemorrhage. Treatment with intravenous thrombolysis within 3 h of symptom onset has become the standard of care in acute ischemic stroke, but the safety and efficacy of this intervention in patients with infective endocarditis is unknown. SUMMARY OF CASE: We report the case of a patient with ischemic stroke who experienced substantial neurological improvement after being treated with intravenous thrombolysis (NIH stroke scale score of 15 on admission and 4 after treatment) and was subsequently found to have acute infective mitral endocarditis. CONCLUSION: Favorable response to thrombolysis may occur in patients with stroke due to infectious endocarditis. The safety of this therapy remains to be established.
INTRODUCTION:Infective endocarditis can lead to serious neurological complications including ischemic stroke and intracranial hemorrhage. Treatment with intravenous thrombolysis within 3 h of symptom onset has become the standard of care in acute ischemic stroke, but the safety and efficacy of this intervention in patients with infective endocarditis is unknown. SUMMARY OF CASE: We report the case of a patient with ischemic stroke who experienced substantial neurological improvement after being treated with intravenous thrombolysis (NIH stroke scale score of 15 on admission and 4 after treatment) and was subsequently found to have acute infective mitral endocarditis. CONCLUSION: Favorable response to thrombolysis may occur in patients with stroke due to infectious endocarditis. The safety of this therapy remains to be established.
Authors: D Georgiadis; O Lanczik; S Schwab; S Engelter; R Sztajzel; M Arnold; M Siebler; S Schwarz; P Lyrer; R W Baumgartner Journal: Neurology Date: 2005-05-10 Impact factor: 9.910
Authors: D J Anderson; L B Goldstein; W E Wilkinson; G R Corey; C H Cabell; L L Sanders; D J Sexton Journal: Neurology Date: 2003-11-25 Impact factor: 9.910
Authors: Philipp Albrecht; Mark Stettner; Leila Husseini; Stephan Macht; Sebastian Jander; Colin Mackenzie; Ulrike Oesterlee; Philipp Slotty; Axel Methner; Hans-Peter Hartung; Orhan Aktas Journal: BMC Neurol Date: 2012-11-05 Impact factor: 2.474