Literature DB >> 17521892

The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults.

Warren D Taylor1, Stephan Züchner, Martha E Payne, Denise F Messer, Tracy J Doty, James R MacFall, John L Beyer, K Ranga R Krishnan.   

Abstract

We examined the relationship between COMT Val158Met genotype and temporal lobe volumes, including the caudate as a control region. Thirty-one healthy subjects completed 1.5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes.

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Year:  2007        PMID： 17521892      PMCID： PMC1950247          DOI： 10.1016/j.pscychresns.2007.01.005

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  14 in total

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  31 in total

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