The effect of platelet-rich plasma on early and late bone healing: an experimental study in goats.

Four round critical-size defects were made in the foreheads of 20 goats. The defects were filled with autogenous particulate cancellous bone, in which 1 ml of platelet-rich plasma (PRP) was added in two of the four defects of each goat. The goats were divided into four subgroups of five goats each, which were killed after 1, 2, 6 and 12 weeks. The results of histologic and histomorphometric examination showed that early and late bone healing was not enhanced when PRP was used.