| Literature DB >> 17521510 |
Giolanta Kogianni1, Brendon S Noble.
Abstract
Osteocytes, the most abundant cell type in bone, remain the least characterized. Several theories have been proposed regarding their function, including osteolysis, sensing the strains produced in response to mechanical loading of bones, and producing signals that affect the function of osteoblasts and osteoclasts and hence, bone turnover. This review also discusses the role of osteocyte apoptosis in targeted bone remodeling and proposes that the occurrence of osteocyte apoptosis is consistent with the description of apoptosis as an essential homeostatic mechanism for the healthy maintenance of tissues.Entities:
Mesh:
Year: 2007 PMID: 17521510 DOI: 10.1007/s11914-007-0007-z
Source DB: PubMed Journal: Curr Osteoporos Rep ISSN: 1544-1873 Impact factor: 5.096