Literature DB >> 17521196

Efficient synthesis of 5-amido-3-hydroxy-4-pyrones as inhibitors of matrix metalloproteinases.

Yi-Long Yan1, Seth M Cohen.   

Abstract

3-hydroxy-4-pyrones are a class of important metal chelators with versatile medicinal applications. An efficient pathway for the preparation of new 5-amido-3-hydroxy-4-pyrone derivatives has been developed. The synthesized 5-amido-3-hydroxy-4-pyrones have been evaluated as inhibitors of matrix metalloproteinases.

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Year:  2007        PMID： 17521196      PMCID： PMC2531216          DOI： 10.1021/ol0707665

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  29 in total

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5.  Potent, selective pyrone-based inhibitors of stromelysin-1.

Authors:  David T Puerta; John Mongan; Ba L Tran; J Andrew McCammon; Seth M Cohen
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6.  Synthesis of 2-amido-3-hydroxypyridin-4(1H)-ones: novel iron chelators with enhanced pFe3+ values.

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Journal:  Bioorg Med Chem       Date:  2001-03       Impact factor: 3.641

7.  Addressing lead toxicity: complexation of lead(II) with thiopyrone and hydroxypyridinethione O,S mixed chelators.

Authors:  Jana A Lewis; Seth M Cohen
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8.  A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases.

Authors:  C G Knight; F Willenbrock; G Murphy
Journal:  FEBS Lett       Date:  1992-01-27       Impact factor: 4.124

9.  New beginnings for matrix metalloproteinase inhibitors: identification of high-affinity zinc-binding groups.

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Journal:  J Am Chem Soc       Date:  2004-07-14       Impact factor: 15.419

Review 10.  The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors.

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Journal:  Curr Med Chem       Date:  2004-11       Impact factor: 4.530
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Journal:  Prog Mol Biol Transl Sci       Date:  2017-05-10       Impact factor: 3.622

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5.  Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease.

Authors:  Cy V Credille; Benjamin L Dick; Christine N Morrison; Ryjul W Stokes; Rebecca N Adamek; Nicholas C Wu; Ian A Wilson; Seth M Cohen
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6.  Synthesis of hydroxypyrone- and hydroxythiopyrone-based matrix metalloproteinase inhibitors: developing a structure-activity relationship.

Authors:  Yi-Long Yan; Melissa T Miller; Yuchen Cao; Seth M Cohen
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7.  Effect of Alpinia zerumbet components on antioxidant and skin diseases-related enzymes.

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  7 in total

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