Literature DB >> 17520536

Increase in the rate of sternal surgical site infection after coronary artery bypass graft: a marker of higher severity of illness.

Mohamad G Fakih1, Mamta Sharma, Riad Khatib, Dorine Berriel-Cass, Susan Meisner, Steven Harrington, Louis Saravolatz.   

Abstract

OBJECTIVE: To evaluate factors related to a gradual rise in sternal surgical site infection (SSI) rates.
DESIGN: Retrospective cohort study.
SETTING: A 608-bed, tertiary care teaching hospital. PATIENTS: All patients who underwent coronary artery bypass graft (CABG) from January 2000 through September 2004.
RESULTS: Of 3,578 patients who underwent CABG, 144 (4%) had sternal SSI. There was an increase in infection rate, with a marked reduction in the number of operations per year. The percentage of patients with peripheral vascular disease increased from 12% to 24.3% (P<.001), and the percentage with congestive heart failure increased from 17% to 22% (P<.001). Between 2002 and 2004, the mean duration of surgery increased from 233 to 290 minutes (P<.001), the percentage of patients with a National Nosocomial Infections Surveillance System (NNIS) risk index of 2 increased from 14.3% to 38% (P<.001), and the percentage of patients with a postoperative stay in the intensive care unit of greater than 72 hours increased from 29% to 40.6% (P<.001). Multivariate analysis showed diabetes mellitus, peripheral vascular disease, obesity, duration of surgery, and postoperative stay in the intensive care unit of greater than 72 hours to be independently associated with infection.
CONCLUSIONS: An increase in infection in the CABG population not associated with an outbreak may be a reflection of a change in the severity of illness. Preoperative, intraoperative, and postoperative markers for increased infection risk may be used, in addition to the NNIS risk index, to assess the patient population risk.

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Year:  2007        PMID: 17520536     DOI: 10.1086/518347

Source DB:  PubMed          Journal:  Infect Control Hosp Epidemiol        ISSN: 0899-823X            Impact factor:   3.254


  10 in total

Review 1.  An update review on risk factors and scales for prediction of deep sternal wound infections.

Authors:  Alessandra Buja; Alessandra Zampieron; Sara Cavalet; Daniele Chiffi; Paolo Sandonà; Angela Vinelli; Tatjana Baldovin; Vincenzo Baldo
Journal:  Int Wound J       Date:  2011-12-08       Impact factor: 3.315

2.  High-dose continuous oxacillin infusion results in achievement of pharmacokinetics targets in critically ill patients with deep sternal wound infections following cardiac surgery.

Authors:  Nicolas Nesseler; Marie-Clémence Verdier; Yoann Launey; Alexandre Malherbe; Marine Dermu; Caroline Piau; Erwan Flécher; Olivier Tribut; Yannick Mallédant; Philippe Seguin
Journal:  Antimicrob Agents Chemother       Date:  2014-06-30       Impact factor: 5.191

3.  Prospective, open-label investigation of the pharmacokinetics of daptomycin during cardiopulmonary bypass surgery.

Authors:  Megan H Nguyen; Samantha J Eells; Jennifer Tan; Corinne T Sheth; Bassam Omari; Margarita Flores; Jeffrey Wang; Loren G Miller
Journal:  Antimicrob Agents Chemother       Date:  2011-03-28       Impact factor: 5.191

4.  Trends in postcoronary artery bypass graft sternal wound dehiscence in a provincial population.

Authors:  Christopher Doherty; Duncan Nickerson; Danielle A Southern; Teresa Kieser; Jehangir Appoo; Jeffery Dawes; Michael A De Souza; Alan R Harrop; Doreen Rabi
Journal:  Plast Surg (Oakv)       Date:  2014       Impact factor: 0.947

Review 5.  Preventing deep wound infection after coronary artery bypass grafting: a review.

Authors:  Charles S Bryan; William M Yarbrough
Journal:  Tex Heart Inst J       Date:  2013

Review 6.  Diabetes and Risk of Surgical Site Infection: A Systematic Review and Meta-analysis.

Authors:  Emily T Martin; Keith S Kaye; Caitlin Knott; Huong Nguyen; Maressa Santarossa; Richard Evans; Elizabeth Bertran; Linda Jaber
Journal:  Infect Control Hosp Epidemiol       Date:  2015-10-27       Impact factor: 3.254

7.  Deep sternal wound infection after cardiac surgery: Evidences and controversies.

Authors:  Paolo Cotogni; Cristina Barbero; Mauro Rinaldi
Journal:  World J Crit Care Med       Date:  2015-11-04

8.  Surgical site infections following coronary artery bypass graft procedures: 10 years of surveillance data.

Authors:  Damin Si; Mohana Rajmokan; Prabha Lakhan; John Marquess; Christopher Coulter; David Paterson
Journal:  BMC Infect Dis       Date:  2014-06-10       Impact factor: 3.090

Review 9.  Latitude of the study place and age of the patient are associated with incidence of mediastinitis and microbiology in open-heart surgery: a systematic review and meta-analysis.

Authors:  M Abdelnoor; Ø A Vengen; O Johansen; I Sandven; A M Abdelnoor
Journal:  Clin Epidemiol       Date:  2016-06-02       Impact factor: 4.790

10.  Coronary artery bypass surgery in Syrian refugees. Outcomes in a Turkish tertiary center.

Authors:  Mazlum Sahin; Semi Öztürk; Tugba I Mert; Gündüz Durmuş; Mehmet Mustafa Can
Journal:  Saudi Med J       Date:  2018-07       Impact factor: 1.484

  10 in total

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