Christian P Karger1, Oliver Jäkel. 1. Abteilung Medizinische Physik in der Strahlentherapie (E040), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. c.karger@dkfz.de
Abstract
BACKGROUND: Worldwide, encouraging clinical results of ion radiotherapy led to planning and construction of several new treatment facilities. MATERIAL AND METHODS: The main technical and biological aspects of ion therapy are reviewed. The current status and future developments are discussed. RESULTS: The use of ions in radiotherapy results in highly conformal dose distributions. The degree of conformality is higher for active than for passive beam delivery techniques. Applying ion therapy, uncertainties in the range and the biologically effective dose have to be considered. For heavy ions, the clinical value of the increased biological efficiency has to be investigated. CONCLUSION: Although the principal methods for clinical application of ion therapy are available, the development must be continued to explore its full potential.
BACKGROUND: Worldwide, encouraging clinical results of ion radiotherapy led to planning and construction of several new treatment facilities. MATERIAL AND METHODS: The main technical and biological aspects of ion therapy are reviewed. The current status and future developments are discussed. RESULTS: The use of ions in radiotherapy results in highly conformal dose distributions. The degree of conformality is higher for active than for passive beam delivery techniques. Applying ion therapy, uncertainties in the range and the biologically effective dose have to be considered. For heavy ions, the clinical value of the increased biological efficiency has to be investigated. CONCLUSION: Although the principal methods for clinical application of ion therapy are available, the development must be continued to explore its full potential.
Authors: Mark Rickhey; Zdenek Morávek; Christoph Eilles; Oliver Koelbl; Ludwig Bogner Journal: Strahlenther Onkol Date: 2010-05-21 Impact factor: 3.621
Authors: Otilija D Keta; Danijela V Todorović; Tanja M Bulat; Pablo Ga Cirrone; Francesco Romano; Giacomo Cuttone; Ivan M Petrović; Aleksandra M Ristić Fira Journal: Exp Biol Med (Maywood) Date: 2016-09-15
Authors: Franz M Wagner; Peter Kneschaurek; Anton Kastenmüller; Birgit Loeper-Kabasakal; Severin Kampfer; Harald Breitkreutz; Wolfgang Waschkowski; Michael Molls; Winfried Petry Journal: Strahlenther Onkol Date: 2008-12-24 Impact factor: 3.621
Authors: Thomas I Marshall; Pankaj Chaudhary; Anna Michaelidesová; Jana Vachelová; Marie Davídková; Vladimir Vondráček; Giuseppe Schettino; Kevin M Prise Journal: Int J Radiat Oncol Biol Phys Date: 2016-02-13 Impact factor: 7.038
Authors: Annelies Suetens; Marjan Moreels; Roel Quintens; Els Soors; Jasmine Buset; Sabina Chiriotti; Kevin Tabury; Vincent Gregoire; Sarah Baatout Journal: J Radiat Res Date: 2014-09-04 Impact factor: 2.724