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Literature DB >> 17520135

Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol.

Michelle Pacholec¹, Jason K Sello, Christopher T Walsh, Michael G Thomas.

Abstract

Herein we report the first biochemical characterization of an enzyme involved in the biosynthesis of chloramphenicol that provides new insights into the origins of the antibiotic.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17520135 DOI： 10.1039/b703356g

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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Cited

15 in total

Review 1. Nitroaromatic compounds, from synthesis to biodegradation.

Authors: Kou-San Ju; Rebecca E Parales
Journal: Microbiol Mol Biol Rev Date: 2010-06 Impact factor: 11.056

Review 2. Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.

Authors: Abraham J Waldman; Tai L Ng; Peng Wang; Emily P Balskus
Journal: Chem Rev Date: 2017-04-04 Impact factor: 60.622

3. An unusual peroxo intermediate of the arylamine oxygenase of the chloramphenicol biosynthetic pathway.

Authors: Thomas M Makris; Van V Vu; Katlyn K Meier; Anna J Komor; Brent S Rivard; Eckard Münck; Lawrence Que; John D Lipscomb
Journal: J Am Chem Soc Date: 2015-01-21 Impact factor: 15.419

4. A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis.

Authors: Thomas M Makris; Mrinmoy Chakrabarti; Eckard Münck; John D Lipscomb
Journal: Proc Natl Acad Sci U S A Date: 2010-08-16 Impact factor: 11.205

5. A Carboxylate Shift Regulates Dioxygen Activation by the Diiron Nonheme β-Hydroxylase CmlA upon Binding of a Substrate-Loaded Nonribosomal Peptide Synthetase.

Authors: Andrew J Jasniewski; Cory J Knoot; John D Lipscomb; Lawrence Que
Journal: Biochemistry Date: 2016-10-07 Impact factor: 3.162

10. Unprecedented (μ-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase CmlI.

Authors: Andrew J Jasniewski; Anna J Komor; John D Lipscomb; Lawrence Que
Journal: J Am Chem Soc Date: 2017-07-19 Impact factor: 15.419

Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol.

Review 1. Nitroaromatic compounds, from synthesis to biodegradation.

Review 2. Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.

3. An unusual peroxo intermediate of the arylamine oxygenase of the chloramphenicol biosynthetic pathway.

4. A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis.

5. A Carboxylate Shift Regulates Dioxygen Activation by the Diiron Nonheme β-Hydroxylase CmlA upon Binding of a Substrate-Loaded Nonribosomal Peptide Synthetase.

Review 6. Diiron monooxygenases in natural product biosynthesis.

7. CmlI is an N-oxygenase in the biosynthesis of chloramphenicol.

Review 8. Understanding and Improving the Activity of Flavin-Dependent Halogenases via Random and Targeted Mutagenesis.

9. Crystal structure of CmlI, the arylamine oxygenase from the chloramphenicol biosynthetic pathway.

10. Unprecedented (μ-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase CmlI.