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Literature DB >> 17520081

Do single seizures cause neuronal death in the human hippocampus?

Luisa L Rocha¹, Maria-Leonor Lopez-Meraz, Jerome Niquet, Claude G Wasterlain.

Abstract

The question of whether repeated single seizures cause neuronal death in the adult human brain is of great clinical importance and might have broad therapeutic implications. Reviewed here are recent studies on the effects of repeated single seizures (in the absence of status epilepticus) on hippocampal volume and on neuronal death markers in blood and in surgically ablated hippocampi.

Entities: Disease Species

Year: 2007 PMID： 17520081 PMCID： PMC1874327 DOI： 10.1111/j.1535-7511.2007.00178.x

Source DB: PubMed Journal: Epilepsy Curr ISSN： 1535-7511 Impact factor: 7.500

50 in total

Review 1. The Bcl-2 protein family: arbiters of cell survival.

Authors: J M Adams; S Cory
Journal: Science Date: 1998-08-28 Impact factor: 47.728

2. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.

Authors: S M Srinivasula; M Ahmad; T Fernandes-Alnemri; E S Alnemri
Journal: Mol Cell Date: 1998-06 Impact factor: 17.970

3. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.

Authors: J Chen; T Nagayama; K Jin; R A Stetler; R L Zhu; S H Graham; R P Simon
Journal: J Neurosci Date: 1998-07-01 Impact factor: 6.167

4. Molecular characterization of mitochondrial apoptosis-inducing factor.

Authors: S A Susin; H K Lorenzo; N Zamzami; I Marzo; B E Snow; G M Brothers; J Mangion; E Jacotot; P Costantini; M Loeffler; N Larochette; D R Goodlett; R Aebersold; D P Siderovski; J M Penninger; G Kroemer
Journal: Nature Date: 1999-02-04 Impact factor: 49.962

5. Morin Prevents Granule Cell Dispersion and Neurotoxicity via Suppression of mTORC1 in a Kainic Acid-induced Seizure Model.

Authors: Ji Min Lee; Jungwan Hong; Gyeong Joon Moon; Un Ju Jung; So-Yoon Won; Sang Ryong Kim
Journal: Exp Neurobiol Date: 2018-06-30 Impact factor: 3.261

5 in total

Do single seizures cause neuronal death in the human hippocampus?

Review 1. The Bcl-2 protein family: arbiters of cell survival.

2. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.

3. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.

4. Molecular characterization of mitochondrial apoptosis-inducing factor.

5. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal.

6. Recurrent seizures may cause hippocampal damage in temporal lobe epilepsy.

7. Serum levels of neuron-specific enolase and s-100 protein after single tonic-clonic seizures.

8. Neuronal cyclin expression in the hippocampus in temporal lobe epilepsy.

9. Neuroimaging evidence of progressive neuronal loss and dysfunction in temporal lobe epilepsy.

10. Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures.

1. Unilateral hippocampal wasting after combined-modality therapy for glioblastoma.

2. Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro.

3. Beneficial Effects of Silibinin Against Kainic Acid-induced Neurotoxicity in the Hippocampus in vivo.

4. Polymorphisms of toll-like receptors 2 and 9 and severity and prognosis of bacterial meningitis in Chinese children.

5. Morin Prevents Granule Cell Dispersion and Neurotoxicity via Suppression of mTORC1 in a Kainic Acid-induced Seizure Model.