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Literature DB >> 17517862

Heterogeneity of a Campylobacter jejuni protein that is secreted through the flagellar filament.

Frédéric Poly¹, Cheryl Ewing, Scarlett Goon, Thomas E Hickey, David Rockabrand, Gary Majam, Lanfong Lee, Julie Phan, Nicholas J Savarino, Patricia Guerry.

Abstract

Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a sigma(28) promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a minimum flagellar structure. The addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in a rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains.

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Year: 2007 PMID： 17517862 PMCID： PMC1951984 DOI： 10.1128/IAI.00159-07

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

50 in total

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2. Structural heterogeneity of carbohydrate modifications affects serospecificity of Campylobacter flagellins.

Authors: Susan M Logan; John F Kelly; Pierre Thibault; Cheryl P Ewing; Patricia Guerry
Journal: Mol Microbiol Date: 2002-10 Impact factor: 3.501

3. Identification of the carbohydrate moieties and glycosylation motifs in Campylobacter jejuni flagellin.

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4. Whole genome comparison of Campylobacter jejuni human isolates using a low-cost microarray reveals extensive genetic diversity.

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5. The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways.

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7. Identification of Campylobacter jejuni ATCC 43431-specific genes by whole microbial genome comparisons.

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8. FlaC, a protein of Campylobacter jejuni TGH9011 (ATCC43431) secreted through the flagellar apparatus, binds epithelial cells and influences cell invasion.

Authors: Y C Song; S Jin; H Louie; D Ng; R Lau; Y Zhang; R Weerasekera; S Al Rashid; L A Ward; S D Der; V L Chan
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9. The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus.

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Journal: Proc Natl Acad Sci U S A Date: 2003-06-16 Impact factor: 11.205

10. Pseudaminic acid, the major modification on Campylobacter flagellin, is synthesized via the Cj1293 gene.

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Authors: Paphavee Lertsethtakarn; Karen M Ottemann; David R Hendrixson
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Authors: C P A de Haan; R Kivistö; M L Hänninen
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3. Genotypical Relationship Between Human and Poultry Strains of Campylobacter jejuni.

Authors: Roberta Torres de Melo; Carolyne Ferreira Dumont; Raquelline Figueiredo Braz; Guilherme Paz Monteiro; Micaela Guidotti Takeuchi; Eduarda Cristina Alves Lourenzatto; Jandra Pacheco Dos Santos; Daise Aparecida Rossi
Journal: Curr Microbiol Date: 2021-06-05 Impact factor: 2.188

Review 4. A capsule conjugate vaccine approach to prevent diarrheal disease caused by Campylobacter jejuni.

Authors: Alexander C Maue; Frédéric Poly; Patricia Guerry
Journal: Hum Vaccin Immunother Date: 2014-03-14 Impact factor: 3.452

5. Identification and analysis of flagellar coexpressed determinants (Feds) of Campylobacter jejuni involved in colonization.

Authors: Angelica M Barrero-Tobon; David R Hendrixson
Journal: Mol Microbiol Date: 2012-03-15 Impact factor: 3.501