| Literature DB >> 17517508 |
Vanya Mantareva1, Veselin Kussovski, Ivan Angelov, Ekaterina Borisova, Latchezar Avramov, Günter Schnurpfeil, Dieter Wöhrle.
Abstract
Photodynamic activity of tetrakis-(3-methylpyridyloxy)- and tetrakis-(4-sulfophenoxy)-phthalocyanine zinc(II) toward the gram-positive Staphylococcus aureus, the gram-negative Pseudomonas aeruginosa, and the fungi Candida albicans was studied. The drug uptake dependency with an inverse behavior to the cell density was observed. The cationic photosensitizer completely inactivated S. aureus and C. albicans, and with 4 log10 P. aeruginosa. The photoinactivation at mild experimental conditions, such as drug dose of 1.5 microM and fluence of 50 mW cm(-2) for 10 min irradiation time, was shown.Entities:
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Year: 2007 PMID： 17517508 DOI： 10.1016/j.bmc.2007.04.069
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641