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Literature DB >> 17516225

Attraction of phagocytes by apoptotic cells is mediated by lysophosphatidylcholine.

Ruediger B Mueller¹, Ahmed Sheriff, Udo S Gaipl, Sebastian Wesselborg, Kirsten Lauber.

Abstract

Apoptotic cells promote the phagocytosis of themselves via the exposure of "eat me" signals. Furthermore, a second, "find me" signal is required to attract phagocytes. In this review the double function of lysophosphatidylcholine for the clearance of apoptotic material as factor leading to attraction of phagocytes as a soluble "find me" signal and opsonisation of apoptotic cells as a membrane bound "eat me" signal is outlined. Lysophosphatidylcholine, exerting this bivalent function, leads to a sufficient clearance of apoptotic cell as a "keep calm" mechanism to prevent activation of the immune system by secondary necrosis.

Entities: Chemical Disease Gene

Mesh：

Substances：
Lysophosphatidylcholines

Year: 2007 PMID： 17516225 DOI： 10.1080/08916930701356911

Source DB: PubMed Journal: Autoimmunity ISSN： 0891-6934 Impact factor: 2.815

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Cited

19 in total

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Journal: Biochim Biophys Acta Date: 2011-04-12

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