Literature DB >> 17513568

RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection.

Samantha Griffiths1, Neil Portman, Philip R Taylor, Siamon Gordon, Michael L Ginger, Keith Gull.   

Abstract

We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen.

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Year:  2007        PMID： 17513568      PMCID： PMC1951115          DOI： 10.1128/EC.00110-07

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  20 in total

1.  Assembly and function of complex flagellar structures illustrated by the paraflagellar rod of trypanosomes.

Authors:  P Bastin; K Gull
Journal:  Protist       Date:  1999-08

2.  Pairwise knockdowns of cdc2-related kinases (CRKs) in Trypanosoma brucei identified the CRKs for G1/S and G2/M transitions and demonstrated distinctive cytokinetic regulations between two developmental stages of the organism.

Authors:  Xiaoming Tu; Ching C Wang
Journal:  Eukaryot Cell       Date:  2005-04

3.  Conserved and specific functions of axoneme components in trypanosome motility.

Authors:  Carole Branche; Linda Kohl; Géraldine Toutirais; Johanna Buisson; Jacky Cosson; Philippe Bastin
Journal:  J Cell Sci       Date:  2006-08-01       Impact factor: 5.285

4.  Changing roles of aurora-B kinase in two life cycle stages of Trypanosoma brucei.

Authors:  Ziyin Li; C C Wang
Journal:  Eukaryot Cell       Date:  2006-07

5.  The RACK1 homologue from Trypanosoma brucei is required for the onset and progression of cytokinesis.

Authors:  Karen G Rothberg; Dara L Burdette; Joy Pfannstiel; Neal Jetton; Rashmi Singh; Larry Ruben
Journal:  J Biol Chem       Date:  2006-02-09       Impact factor: 5.157

Review 6.  Both IgM and IgG anti-VSG antibodies initiate a cycle of aggregation-disaggregation of bloodstream forms of Trypanosoma brucei without damage to the parasite.

Authors:  C O'Beirne; C M Lowry; H P Voorheis
Journal:  Mol Biochem Parasitol       Date:  1998-03-01       Impact factor: 1.759

7.  Trypanosoma brucei MOB1 is required for accurate and efficient cytokinesis but not for exit from mitosis.

Authors:  Tansy C Hammarton; Simon G Lillico; Sue C Welburn; Jeremy C Mottram
Journal:  Mol Microbiol       Date:  2005-04       Impact factor: 3.501

8.  Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes.

Authors:  Karen Sheader; Sue Vaughan; James Minchin; Katie Hughes; Keith Gull; Gloria Rudenko
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-03       Impact factor: 11.205

9.  Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes.

Authors:  Katherine S Ralston; Kent L Hill
Journal:  PLoS Pathog       Date:  2006-09       Impact factor: 6.823

10.  Flagellar motility is required for the viability of the bloodstream trypanosome.

Authors:  Richard Broadhead; Helen R Dawe; Helen Farr; Samantha Griffiths; Sarah R Hart; Neil Portman; Michael K Shaw; Michael L Ginger; Simon J Gaskell; Paul G McKean; Keith Gull
Journal:  Nature       Date:  2006-03-09       Impact factor: 49.962
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  20 in total

Review 1.  Touching the Surface: Diverse Roles for the Flagellar Membrane in Kinetoplastid Parasites.

Authors:  Felice D Kelly; Marco A Sanchez; Scott M Landfear
Journal:  Microbiol Mol Biol Rev       Date:  2020-04-01       Impact factor: 11.056

Review 2.  The paraflagellar rod of kinetoplastid parasites: from structure to components and function.

Authors:  Neil Portman; Keith Gull
Journal:  Int J Parasitol       Date:  2009-10-30       Impact factor: 3.981

Review 3.  The Trypanosoma brucei flagellum: moving parasites in new directions.

Authors:  Katherine S Ralston; Zakayi P Kabututu; Jason H Melehani; Michael Oberholzer; Kent L Hill
Journal:  Annu Rev Microbiol       Date:  2009       Impact factor: 15.500

4.  TcI Isolates of Trypanosoma cruzi Exploit the Antioxidant Network for Enhanced Intracellular Survival in Macrophages and Virulence in Mice.

Authors:  María Paola Zago; Yashoda M Hosakote; Sue-Jie Koo; Monisha Dhiman; María Dolores Piñeyro; Adriana Parodi-Talice; Miguel A Basombrio; Carlos Robello; Nisha J Garg
Journal:  Infect Immun       Date:  2016-05-24       Impact factor: 3.441

Review 5.  The flagellum of Trypanosoma brucei: new tricks from an old dog.

Authors:  Katherine S Ralston; Kent L Hill
Journal:  Int J Parasitol       Date:  2008-03-28       Impact factor: 3.981

Review 6.  The eukaryotic flagellum makes the day: novel and unforeseen roles uncovered after post-genomics and proteomics data.

Authors:  Michely C Diniz; Ana Carolina L Pacheco; Kaio M Farias; Diana M de Oliveira
Journal:  Curr Protein Pept Sci       Date:  2012-09       Impact factor: 3.272

7.  Trypanosome motion represents an adaptation to the crowded environment of the vertebrate bloodstream.

Authors:  Niko Heddergott; Timothy Krüger; Sujin B Babu; Ai Wei; Erik Stellamanns; Sravanti Uppaluri; Thomas Pfohl; Holger Stark; Markus Engstler
Journal:  PLoS Pathog       Date:  2012-11-15       Impact factor: 6.823

8.  A Trypanosoma brucei protein required for maintenance of the flagellum attachment zone and flagellar pocket ER domains.

Authors:  Sylvain Lacomble; Sue Vaughan; Michaël Deghelt; Flávia Fernandes Moreira-Leite; Keith Gull
Journal:  Protist       Date:  2011-12-18

9.  A protein-protein interaction map of the Trypanosoma brucei paraflagellar rod.

Authors:  Sylvain Lacomble; Neil Portman; Keith Gull
Journal:  PLoS One       Date:  2009-11-03       Impact factor: 3.240

10.  Global proteomic analysis in trypanosomes reveals unique proteins and conserved cellular processes impacted by arginine methylation.

Authors:  Kaylen Lott; Jun Li; John C Fisk; Hao Wang; John M Aletta; Jun Qu; Laurie K Read
Journal:  J Proteomics       Date:  2013-07-19       Impact factor: 4.044
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