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Literature DB >> 17512739

RNA as scaffold for pyrene excited complexes.

Christian Grünewald¹, Taewoo Kwon, Nelly Piton, Ute Förster, Josef Wachtveitl, Joachim W Engels.

Abstract

Synthesis and spectral properties of 1-ethynylpyrene base modified RNA are reported. The fluorophore attached to the 2-position of adenosine is directed into the easily accessible minor groove in RNA. Through an intermolecular interaction of the pyrene residues in twofold labelled RNA, single and double strands can be distinguished by their fluorescence maxima around 450 and 480 nm, respectively. This behaviour allows the kinetic investigation of RNA hybridisation and folding by fluorescence spectroscopy.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17512739 DOI： 10.1016/j.bmc.2007.04.058

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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Cited

9 in total

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Authors: Renatus W Sinkeldam; Nicholas J Greco; Yitzhak Tor
Journal: Chem Rev Date: 2010-05-12 Impact factor: 60.622

2. Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamer.

Authors: Henrik Gustmann; Anna-Lena J Segler; Dnyaneshwar B Gophane; Andreas J Reuss; Christian Grünewald; Markus Braun; Julia E Weigand; Snorri Th Sigurdsson; Josef Wachtveitl
Journal: Nucleic Acids Res Date: 2019-01-10 Impact factor: 16.971

Review 3. DNA-multichromophore systems.

Authors: Yin Nah Teo; Eric T Kool
Journal: Chem Rev Date: 2012-03-16 Impact factor: 60.622

4. Paramagnetic-iterative relaxation matrix approach: extracting PRE-restraints from NOESY spectra for 3D structure elucidation of biomolecules.

Authors: E C Cetiner; H R A Jonker; C Helmling; D B Gophane; C Grünewald; S Th Sigurdsson; H Schwalbe
Journal: J Biomol NMR Date: 2019-10-12 Impact factor: 2.835

5. Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.

Authors: Sujay P Sau; Andreas S Madsen; Peter Podbevsek; Nicolai K Andersen; T Santhosh Kumar; Sanne Andersen; Rie L Rathje; Brooke A Anderson; Dale C Guenther; Saswata Karmakar; Pawan Kumar; Janez Plavec; Jesper Wengel; Patrick J Hrdlicka
Journal: J Org Chem Date: 2013-09-25 Impact factor: 4.354

RNA as scaffold for pyrene excited complexes.

Review 1. Fluorescent analogs of biomolecular building blocks: design, properties, and applications.

2. Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamer.

Review 3. DNA-multichromophore systems.

4. Paramagnetic-iterative relaxation matrix approach: extracting PRE-restraints from NOESY spectra for 3D structure elucidation of biomolecules.

5. Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.

6. "End-to-end" stacking of small dsRNA.

Review 7. Synthesis of Nucleobase-Modified RNA Oligonucleotides by Post-Synthetic Approach.

8. A₃ Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity.

9. Visibly emissive and responsive extended 6-aza-uridines.

RNA as scaffold for pyrene excited complexes.

Review 1. Fluorescent analogs of biomolecular building blocks: design, properties, and applications.

2. Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamer.

Review 3. DNA-multichromophore systems.

4. Paramagnetic-iterative relaxation matrix approach: extracting PRE-restraints from NOESY spectra for 3D structure elucidation of biomolecules.

5. Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.

6. "End-to-end" stacking of small dsRNA.

Review 7. Synthesis of Nucleobase-Modified RNA Oligonucleotides by Post-Synthetic Approach.

8. A3 Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity.

9. Visibly emissive and responsive extended 6-aza-uridines.

8. A₃ Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity.