Literature DB >> 17512723

RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism.

Brigitte Keller1, Jerzy Adamski.   

Abstract

Three retinol dehydrogenases (RDHs) were tested for steroid converting abilities: human and murine RDH 12 and human RDH13. RDH12 is involved in retinal degeneration in Leber's congenital amaurosis (LCA). We show that murine Rdh12 and human RDH13 do not reveal activity towards the checked steroids, but that human type 12 RDH reduces dihydrotestosterone to androstanediol, and is thus also involved in steroid metabolism. Furthermore, we analyzed both expression and subcellular localization of these enzymes.

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Year:  2007        PMID： 17512723     DOI： 10.1016/j.jsbmb.2007.03.015

Source DB:  PubMed          Journal:  J Steroid Biochem Mol Biol        ISSN： 0960-0760            Impact factor:   4.292


  12 in total

1.  Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain.

Authors:  Natalia Mast; Rachel Reem; Ilya Bederman; Suber Huang; Pier Luigi DiPatre; Ingemar Bjorkhem; Irina A Pikuleva
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-02-01       Impact factor: 4.799

2.  ACTH is a potent regulator of gene expression in human adrenal cells.

Authors:  Yewei Xing; C Richard Parker; Michael Edwards; William E Rainey
Journal:  J Mol Endocrinol       Date:  2010-05-11       Impact factor: 5.098

3.  Yeast ENV9 encodes a conserved lipid droplet (LD) short-chain dehydrogenase involved in LD morphology.

Authors:  Ikha M Siddiqah; Surya P Manandhar; Stephanie M Cocca; Teli Hsueh; Vanessa Cervantes; Editte Gharakhanian
Journal:  Curr Genet       Date:  2017-05-24       Impact factor: 3.886

4.  Associations Between Fundus Types and Clinical Manifestations in Patients with RDH12 Gene Mutations.

Authors:  Jing Jin; Liang Liang; Kun Jin; Hai-Jiang Zhang; Rong Liu; Yin Shen
Journal:  Brain Topogr       Date:  2022-01-10       Impact factor: 4.275

5.  Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity.

Authors:  Olga V Belyaeva; Olga V Korkina; Anton V Stetsenko; Natalia Y Kedishvili
Journal:  FEBS J       Date:  2007-11-26       Impact factor: 5.542

6.  Rdh12 activity and effects on retinoid processing in the murine retina.

Authors:  Jared D Chrispell; Kecia L Feathers; Maureen A Kane; Chul Y Kim; Matthew Brooks; Ritu Khanna; Ingo Kurth; Christian A Hübner; Andreas Gal; Alan J Mears; Anand Swaroop; Joseph L Napoli; Janet R Sparrow; Debra A Thompson
Journal:  J Biol Chem       Date:  2009-06-08       Impact factor: 5.157

Review 7.  Medium- and short-chain dehydrogenase/reductase gene and protein families : Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism.

Authors:  X Parés; J Farrés; N Kedishvili; G Duester
Journal:  Cell Mol Life Sci       Date:  2008-12       Impact factor: 9.261

Review 8.  Enzymology of retinoic acid biosynthesis and degradation.

Authors:  Natalia Y Kedishvili
Journal:  J Lipid Res       Date:  2013-04-29       Impact factor: 5.922

9.  Retinol dehydrogenase 13 protects the mouse retina from acute light damage.

Authors:  Haiyan Wang; Xiaofang Cui; Qing Gu; Yan Chen; Jia Zhou; Ying Kuang; Zhugang Wang; Xun Xu
Journal:  Mol Vis       Date:  2012-04-24       Impact factor: 2.367

Review 10.  Generation of Retinaldehyde for Retinoic Acid Biosynthesis.

Authors:  Olga V Belyaeva; Mark K Adams; Kirill M Popov; Natalia Y Kedishvili
Journal:  Biomolecules       Date:  2019-12-18
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