| Literature DB >> 17512722 |
Teresa Juárez-Cedillo1, Maite Vallejo, José Manuel Fragoso, Dulce Maria Hernández-Hernández, José Manuel Rodríguez-Pérez, Sergio Sánchez-García, María del Carmen García-Peña, Alejandro García-Carrancá, Alejandro Mohar-Betancourt, Julio Granados, Gilberto Vargas-Alarcón.
Abstract
The aim of the study was to evaluate the association of two CYP1A1 polymorphisms (Msp1 and exon 7) with cervical cancer in Mexican women considering their smoking habit. The polymorphisms were determined in 310 individuals (155 with cervical cancer and 155 healthy controls). Women with MspI T/C or C/C showed increased risk of developing cervical cancer (3.7- and 8.3-fold increase, respectively) compared to women with T/T genotype. When smoking habit was considered, the risk for non-smokers with T/C and C/C genotypes was similar (5.2 and 4.1, respectively), whereas smoking women with C/C genotype showed a 19.4-fold increase of cervical cancer. Number of child births, number of sexual partners and marital status were strong risk factors for developing cervical cancer in women with T/T genotype; however, in women with T/C genotype, only the number of child births and sexual partners had a significant influence. These results suggest an important role of the CYP1A1 MspI polymorphism in the risk of developing cervical cancer.Entities:
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Year: 2007 PMID： 17512722 DOI： 10.1016/j.ejca.2007.03.025
Source DB: PubMed Journal: Eur J Cancer ISSN： 0959-8049 Impact factor: 9.162