| Literature DB >> 17512587 |
Patrizia Chiusolo1, Giovanni Reddiconto, Giuliana Farina, Alice Mannocci, Alessia Fiorini, Mariangela Palladino, Giuseppe La Torre, Luana Fianchi, Federica Sorà, Luca Laurenti, Giuseppe Leone, Simona Sica.
Abstract
Recently the influence of polymorphisms of different genes involved in metabolism of chemoterapic agents have been studied especially in childhood acute lymphoblastic leukemia (ALL). We evaluated the influence of C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms on time to relapse and survival and on methotrexate (MTX) toxicity in 82 ALL adult patients. Relapse free survival and event free survival between homozygous wild-type and variant patients in both polymorphisms were not significantly different. However, we observed an association between 677TT variant and survival in a subset of ALL patients homogenously treated with MTX-based maintenance (p=0.02). In the same subgroup we confirmed the role of 677TT variant on toxicity during MTX treatment (p=0.003).Entities:
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Year: 2007 PMID： 17512587 DOI： 10.1016/j.leukres.2007.03.028
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156