OBJECTIVES: Because systemic vasculitis (SV) predisposes to atherosclerosis, and high-density lipoprotein (HDL) prevents atherosclerosis by "reverse cholesterol transport" and by inhibiting low-density lipoprotein (LDL) oxidation thanks to apolipoprotein A-I (Apo-AI) and paraoxonase 1 (PON1), we assessed whether LDL oxidation was increased in SV and associated with less PON1 activity. METHODS: The sera of 33 patients with active SV (ASV), 32 in full remission of SV (RSV) and 20 healthy subjects (HS) were analyzed for C-reactive protein (CRP), high-sensitivity-CRP, lipids, lipoproteins, apolipoproteins, PON1 activity, LDL-immune complexes (LDL-IC), and auto-antibodies to oxidized-LDL (ox-LDL), and anticardiolipin antibodies. RESULTS: CRP was higher in ASV than RSV and HS, and negatively correlated with HDL-cholesterol and Apo-AI. Autoantibodies to ox-LDL and highly oxidized malondialdehyde-LDL were higher in RSV than ASV and HS (P<0.05). LDL-IC titers were higher in ASV than RSV and HS (P<0.05). PON1 activity was lower in ASV and RSV than HS (P=0.02). A trend toward a negative correlation between basal PON1 activity and anti-MDA-LDL antibodies (P=0.06) was observed. CONCLUSION: Inflammatory markers in SV were associated with a modified lipoprotein profile, which could lower PON1 activity and contribute to increased ox-LDL titers and accelerated atherosclerosis development.
OBJECTIVES: Because systemic vasculitis (SV) predisposes to atherosclerosis, and high-density lipoprotein (HDL) prevents atherosclerosis by "reverse cholesterol transport" and by inhibiting low-density lipoprotein (LDL) oxidation thanks to apolipoprotein A-I (Apo-AI) and paraoxonase 1 (PON1), we assessed whether LDL oxidation was increased in SV and associated with less PON1 activity. METHODS: The sera of 33 patients with active SV (ASV), 32 in full remission of SV (RSV) and 20 healthy subjects (HS) were analyzed for C-reactive protein (CRP), high-sensitivity-CRP, lipids, lipoproteins, apolipoproteins, PON1 activity, LDL-immune complexes (LDL-IC), and auto-antibodies to oxidized-LDL (ox-LDL), and anticardiolipin antibodies. RESULTS:CRP was higher in ASV than RSV and HS, and negatively correlated with HDL-cholesterol and Apo-AI. Autoantibodies to ox-LDL and highly oxidized malondialdehyde-LDL were higher in RSV than ASV and HS (P<0.05). LDL-IC titers were higher in ASV than RSV and HS (P<0.05). PON1 activity was lower in ASV and RSV than HS (P=0.02). A trend toward a negative correlation between basal PON1 activity and anti-MDA-LDL antibodies (P=0.06) was observed. CONCLUSION: Inflammatory markers in SV were associated with a modified lipoprotein profile, which could lower PON1 activity and contribute to increased ox-LDL titers and accelerated atherosclerosis development.
Authors: Boris L Vaisman; Stephen J Demosky; John A Stonik; Mona Ghias; Cathy L Knapper; Maureen L Sampson; Cuilian Dai; Stewart J Levine; Alan T Remaley Journal: J Lipid Res Date: 2011-10-27 Impact factor: 5.922
Authors: Ramazan Esen; Mehmet Aslan; Mehmet Emin Kucukoglu; Aytekin Cıkman; Umit Yakan; Mahmut Sunnetcioglu; Sahbettin Selek Journal: Wien Klin Wochenschr Date: 2015-02-24 Impact factor: 1.704