| Literature DB >> 17512397 |
Liliane Michalik1, Walter Wahli.
Abstract
Retinoic acid-the active metabolite of vitamin A-influences biological processes by activating the retinoic acid receptor (RAR). In this issue, Schug et al. (2007) demonstrate that retinoic acid also activates the peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta). Remarkably, retinoic acid signaling through RAR or PPARbeta/delta-which depends on cytoplasmic retinoic acid transporters-commits the cell to opposite fates, apoptosis or survival, respectively.Entities:
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Year: 2007 PMID: 17512397 DOI: 10.1016/j.cell.2007.05.001
Source DB: PubMed Journal: Cell ISSN: 0092-8674 Impact factor: 41.582