| Literature DB >> 17512078 |
Abstract
The products of biotechnology, recombinant proteins, monoclonal antibodies, antisense, RNA interference, or non-viral gene transfer, cannot be developed as pharmaceuticals for the brain, unless these molecules are re-formulated to enable transport across the blood-brain barrier (BBB). Large molecule drugs, and plasmid DNA, can be delivered across the BBB with receptor-specific molecular Trojan horses. Trojan horse BBB delivery systems, coupled with one of 3 different technology platforms (fusion proteins, avidin-biotin, or Trojan horse liposomes), can enable the BBB transport of virtually any large molecule drug or plasmid DNA.Entities:
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Year: 2007 PMID： 17512078 PMCID： PMC2701689 DOI： 10.1016/j.jconrel.2007.04.001
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776