| Literature DB >> 17511692 |
M Okazaki1, A S Krupnick, C G Kornfeld, J M Lai, J H Ritter, S B Richardson, H J Huang, N A Das, G A Patterson, A E Gelman, D Kreisel.
Abstract
Outcomes after lung transplantation are markedly inferior to those after other solid organ transplants. A better understanding of cellular and molecular mechanisms contributing to lung graft injury will be critical to improve outcomes. Advances in this field have been hampered by the lack of a mouse model of lung transplantation. Here, we report a mouse model of vascularized aerated single lung transplantation utilizing cuff techniques. We show that syngeneic grafts have normal histological appearance with minimal infiltration of T lymphocytes. Allogeneic grafts show acute cellular rejection with infiltration of T lymphocytes and recipient-type antigen presenting cells. Our data show that we have developed a physiological model of lung transplantation in the mouse, which provides ample opportunity for the study of nonimmune and immune mechanisms that contribute to lung allograft injury.Entities:
Mesh：
Year: 2007 PMID： 17511692 DOI： 10.1111/j.1600-6143.2007.01819.x
Source DB: PubMed Journal: Am J Transplant ISSN： 1600-6135 Impact factor: 8.086