| Literature DB >> 17511691 |
M Narayanan1, J Szymanski, E Slavcheva, A Rao, A Kelly, K Jones, G Jaffers.
Abstract
Polyomaviruses, including BK and JC viruses, have been associated with graft failure, but have not commonly been associated with malignancy. We present a case of renal cell carcinoma arising in an allograft kidney, in which the tumor and metastasis contain viral DNA. Tumor and biopsy specimens from this patient were examined with hematoxylin & eosin, immunohistochemistry (IHC) and in situ hybridization (ISH). The results were confirmed by real-time polymerase chain reaction (PCR) analysis with BKV primers. Other viruses including herpes simplex 1-2, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and varicella zoster were not detected. The presence of BKV DNA in a renal cell carcinoma, including a metastatic focus, adds to the evidence that this virus may play a role in cancers of the kidney and urinary tract.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17511691 DOI： 10.1111/j.1600-6143.2007.01817.x
Source DB: PubMed Journal: Am J Transplant ISSN： 1600-6135 Impact factor: 8.086