Literature DB >> 17511659

Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs?

S Curry1, N Roqué-Rosell, T R Sweeney, P A Zunszain, R J Leatherbarrow.   

Abstract

Foot-and-mouth disease virus causes a major global agricultural problem that is difficult to control with existing vaccines. Structural analyses of the viral 3C protease not only have provided fresh insights into the catalytic mechanism of an unusual class of chymotrypsin-like cysteine proteases, but also are generating valuable information to drive the quest for effective antiviral therapies.

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Year:  2007        PMID： 17511659     DOI： 10.1042/BST0350594

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  7 in total

1.  Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity.

Authors:  Yen-Hua Huang; Michelle L Colgrave; Richard J Clark; Andrew C Kotze; David J Craik
Journal:  J Biol Chem       Date:  2010-01-26       Impact factor: 5.157

2.  Shifts in the selection-drift balance drive the evolution and epidemiology of foot-and-mouth disease virus.

Authors:  Damien C Tully; Mario A Fares
Journal:  J Virol       Date:  2008-11-12       Impact factor: 5.103

3.  Crystal structure of the 3C protease from Southern African Territories type 2 foot-and-mouth disease virus.

Authors:  Jingjie Yang; Eoin N Leen; Francois F Maree; Stephen Curry
Journal:  PeerJ       Date:  2016-04-26       Impact factor: 2.984

4.  Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate.

Authors:  Patricia A Zunszain; Stephen R Knox; Trevor R Sweeney; Jingjie Yang; Núria Roqué-Rosell; Graham J Belsham; Robin J Leatherbarrow; Stephen Curry
Journal:  J Mol Biol       Date:  2009-10-31       Impact factor: 5.469

Review 5.  Live Cell Reporter Systems for Positive-Sense Single Strand RNA Viruses.

Authors:  Linzhu Ren; Zhiyuan Peng; Xinrong Chen; Hongsheng Ouyang
Journal:  Appl Biochem Biotechnol       Date:  2016-01-04       Impact factor: 2.926

6.  The DDX23 Negatively Regulates Translation and Replication of Foot-and-Mouth Disease Virus and Is Degraded by 3C Proteinase.

Authors:  Sahibzada Waheed Abdullah; Shichong Han; Jin'en Wu; Yun Zhang; Manyuan Bai; Ye Jin; Xiaoying Zhi; Junyong Guan; Shiqi Sun; Huichen Guo
Journal:  Viruses       Date:  2020-11-25       Impact factor: 5.048

7.  Synthesis and Initial Evaluation of a Novel Fluorophore for Selective FMDV 3C Protease Detection.

Authors:  Samerah Malik; Alex Sinclair; Ali Ryan; Adam Le Gresley
Journal:  Molecules       Date:  2020-08-07       Impact factor: 4.411
  7 in total

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