| Literature DB >> 17509924 |
Shin-ichiro Kubo1, Akira Iwatake, Nobuyuki Ebihara, Akira Murakami, Nobutaka Hattori.
Abstract
A 61-year-old man with Parkinson's disease (PD) developed sudden-onset visual impairment after initiation of amantadine treatment. Ophthalmologic examination revealed corneal endothelial edema. Discontinuation of amantadine resulted in rapid improvement of visual acuity. A review of the literature indicated only a few reports of amantadine-associated corneal dysfunction in patients with neurological disorders as well as influenza syndrome, but none with PD. Amantadine-associated visual impairment in PD could be possibly overlooked, since PD mainly affects elderly people who often develop aging-related ocular changes. The present report alerts neurologists and physicians in general to the peculiar ophthalmologic side effect of amantadine.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17509924 DOI： 10.1016/j.parkreldis.2007.03.003
Source DB: PubMed Journal: Parkinsonism Relat Disord ISSN： 1353-8020 Impact factor: 4.891