Literature DB >> 17508027

Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation.

Leonardo Salmena1, Pier Paolo Pandolfi.   

Abstract

Recent studies have shown that three major tumour-suppressor proteins undergo monoubiquitylation-mediated nuclear-cytoplasmic shuttling. Importantly, this mechanism has consequences for cancer and implies that proper localization is central to the function of tumour suppressors. This Progress article highlights recent efforts demonstrating that monoubiquitylation coupled to nuclear-cytoplasmic shuttling might be a novel regulatory mechanism that directly influences the function of tumour suppressors.

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Year:  2007        PMID： 17508027     DOI： 10.1038/nrc2145

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  38 in total

1.  The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.

Authors:  Eugenia Karousou; Masaru Kamiryo; Spyros S Skandalis; Aino Ruusala; Trias Asteriou; Alberto Passi; Hidetoshi Yamashita; Ulf Hellman; Carl-Henrik Heldin; Paraskevi Heldin
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Review 2.  HTLV-1 p13, a small protein with a busy agenda.

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3.  Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children.

Authors:  Maoxiang Qian; Xujie Zhao; Meenakshi Devidas; Wenjian Yang; Yoshihiro Gocho; Colton Smith; Julie M Gastier-Foster; Yizhen Li; Heng Xu; Shouyue Zhang; Sima Jeha; Xiaowen Zhai; Takaomi Sanda; Stuart S Winter; Kimberly P Dunsmore; Elizabeth A Raetz; William L Carroll; Naomi J Winick; Karen R Rabin; Patrick A Zweidler-Mckay; Brent Wood; Ching-Hon Pui; William E Evans; Stephen P Hunger; Charles G Mullighan; Mary V Relling; Mignon L Loh; Jun J Yang
Journal:  J Natl Cancer Inst       Date:  2019-12-01       Impact factor: 13.506

Review 4.  Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting.

Authors:  Georgina S Butler; Christopher M Overall
Journal:  Nat Rev Drug Discov       Date:  2009-12       Impact factor: 84.694

5.  Nucleo-cytoplasmic localization domains regulate Krüppel-like factor 6 (KLF6) protein stability and tumor suppressor function.

Authors:  Estefanía Rodríguez; Nana Aburjania; Nolan M Priedigkeit; Analisa DiFeo; John A Martignetti
Journal:  PLoS One       Date:  2010-09-09       Impact factor: 3.240

6.  Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein.

Authors:  Barbara Monti; Valentina Gatta; Francesca Piretti; Simonetta S Raffaelli; Marco Virgili; Antonio Contestabile
Journal:  Neurotox Res       Date:  2009-07-21       Impact factor: 3.911

7.  A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells.

Authors:  Hongyun Li; Linda L Xu; Katsuaki Masuda; Eliza Raymundo; David G McLeod; Albert Dobi; Shiv Srivastava
Journal:  J Biol Chem       Date:  2008-08-14       Impact factor: 5.157

8.  Lysine conservation and context in TGFbeta and Wnt signaling suggest new targets and general themes for posttranslational modification.

Authors:  Charlotte E Konikoff; Robert G Wisotzkey; Stuart J Newfeld
Journal:  J Mol Evol       Date:  2008-09-17       Impact factor: 2.395

Review 9.  HAF : the new player in oxygen-independent HIF-1alpha degradation.

Authors:  Mei Yee Koh; Garth Powis
Journal:  Cell Cycle       Date:  2009-05-01       Impact factor: 4.534

10.  AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells.

Authors:  Madhu A Lal; Dongsoon Bae; Tura C Camilli; Steven R Patierno; Susan Ceryak
Journal:  Cell Cycle       Date:  2009-05-25       Impact factor: 4.534
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