Literature DB >> 17507611

Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia?

Denise Daley1, Wendi Morgan, Susan Lewis, Joseph Willis, Robert C Elston, Sanford D Markowitz, Georgia L Wiesner.   

Abstract

Our analysis definitely excludes the possibility of the TGFBR1*6A allele increasing the risk of colorectal neoplasia in our sample population. A recent study validating linkage of colorectal cancer to chromosome 9q also excluded the TGFBR1*6A allele as a disease-causing variant in that sample. We conclude that there remains an unidentified susceptibility locus in the region 9q22.2-31.2.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17507611     DOI： 10.1158/1055-9965.EPI-06-0965

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  6 in total

1.  Comprehensive assessment of variation at the transforming growth factor beta type 1 receptor locus and colorectal cancer predisposition.

Authors:  Luis G Carvajal-Carmona; Mike Churchman; Carolina Bonilla; Axel Walther; Jeremie H Lefèvre; David Kerr; Malcolm Dunlop; Richard Houlston; Walter F Bodmer; Ian Tomlinson
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-05       Impact factor: 11.205

2.  Debate about TGFBR1 and the susceptibility to colorectal cancer.

Authors:  Laura Valle
Journal:  World J Gastrointest Oncol       Date:  2012-01-15

3.  Evidence of linkage to chromosomes 10p15.3-p15.1, 14q24.3-q31.1 and 9q33.3-q34.3 in non-syndromic colorectal cancer families.

Authors:  Ian W Saunders; Jason Ross; Finlay Macrae; Graeme P Young; Ignacio Blanco; Jesper Brohede; Glenn Brown; Diana Brookes; Trevor Lockett; Peter L Molloy; Victor Moreno; Gabriel Capella; Garry N Hannan
Journal:  Eur J Hum Genet       Date:  2011-08-10       Impact factor: 4.246

4.  Little evidence for association between the TGFBR1*6A variant and colorectal cancer: a family-based association study on non-syndromic family members from Australia and Spain.

Authors:  Jason P Ross; Linda J Lockett; Bruce Tabor; Ian W Saunders; Graeme P Young; Finlay Macrae; Ignacio Blanco; Gabriel Capella; Glenn S Brown; Trevor J Lockett; Garry N Hannan
Journal:  BMC Cancer       Date:  2014-07-01       Impact factor: 4.430

Review 5.  Role of TGF-Beta and Smad7 in Gut Inflammation, Fibrosis and Cancer.

Authors:  Carmine Stolfi; Edoardo Troncone; Irene Marafini; Giovanni Monteleone
Journal:  Biomolecules       Date:  2020-12-27

6.  TGFBR1 variants TGFBR1(*)6A and Int7G24A are not associated with an increased familial colorectal cancer risk.

Authors:  J Skoglund Lundin; J Vandrovcova; B Song; X Zhou; M Zelada-Hedman; B Werelius; R S Houlston; A Lindblom
Journal:  Br J Cancer       Date:  2009-04-28       Impact factor: 7.640
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.