Literature DB >> 17507468

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.

Hayley Crawford1, Julia G Prado, Alasdair Leslie, Stéphane Hué, Isobella Honeyborne, Sharon Reddy, Mary van der Stok, Zenele Mncube, Christian Brander, Christine Rousseau, James I Mullins, Richard Kaslow, Paul Goepfert, Susan Allen, Eric Hunter, Joseph Mulenga, Photini Kiepiela, Bruce D Walker, Philip J R Goulder.   

Abstract

HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope. These data may help explain the observed association between HLA-B*5703 and long-term control of viremia.

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Year:  2007        PMID： 17507468      PMCID： PMC1951305          DOI： 10.1128/JVI.00465-07

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  33 in total

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Journal:  Science       Date:  2002-05-24       Impact factor: 47.728

2.  Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.

Authors:  Marcus Altfeld; Marylyn M Addo; Eric S Rosenberg; Frederick M Hecht; Paul K Lee; Martin Vogel; Xu G Yu; Rika Draenert; Mary N Johnston; Daryld Strick; Todd M Allen; Margaret E Feeney; James O Kahn; Rafick P Sekaly; Jay A Levy; Jürgen K Rockstroh; Philip J Goulder; Bruce D Walker
Journal:  AIDS       Date:  2003-12-05       Impact factor: 4.177

3.  A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.

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Journal:  Syst Biol       Date:  2003-10       Impact factor: 15.683

4.  Reversion of CTL escape-variant immunodeficiency viruses in vivo.

Authors:  Thomas C Friedrich; Elizabeth J Dodds; Levi J Yant; Lara Vojnov; Richard Rudersdorf; Candice Cullen; David T Evans; Ronald C Desrosiers; Bianca R Mothé; John Sidney; Alessandro Sette; Kevin Kunstman; Steven Wolinsky; Michael Piatak; Jeffrey Lifson; Austin L Hughes; Nancy Wilson; David H O'Connor; David I Watkins
Journal:  Nat Med       Date:  2004-02-15       Impact factor: 53.440

5.  Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolution.

Authors:  Bin Li; Adrianne D Gladden; Marcus Altfeld; John M Kaldor; David A Cooper; Anthony D Kelleher; Todd M Allen
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6.  Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1.

Authors:  Jianming Tang; Shenghui Tang; Elena Lobashevsky; Angela D Myracle; Ulgen Fideli; Grace Aldrovandi; Susan Allen; Rosemary Musonda; Richard A Kaslow
Journal:  J Virol       Date:  2002-08       Impact factor: 5.103

7.  HIV evolution: CTL escape mutation and reversion after transmission.

Authors:  A J Leslie; K J Pfafferott; P Chetty; R Draenert; M M Addo; M Feeney; Y Tang; E C Holmes; T Allen; J G Prado; M Altfeld; C Brander; C Dixon; D Ramduth; P Jeena; S A Thomas; A St John; T A Roach; B Kupfer; G Luzzi; A Edwards; G Taylor; H Lyall; G Tudor-Williams; V Novelli; J Martinez-Picado; P Kiepiela; B D Walker; P J R Goulder
Journal:  Nat Med       Date:  2004-02-08       Impact factor: 53.440

8.  Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection.

Authors:  P J Goulder; M A Altfeld; E S Rosenberg; T Nguyen; Y Tang; R L Eldridge; M M Addo; S He; J S Mukherjee; M N Phillips; M Bunce; S A Kalams; R P Sekaly; B D Walker; C Brander
Journal:  J Exp Med       Date:  2001-01-15       Impact factor: 14.307

9.  Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.

Authors:  Rika Draenert; Sylvie Le Gall; Katja J Pfafferott; Alasdair J Leslie; Polan Chetty; Christian Brander; Edward C Holmes; Shih-Chung Chang; Margaret E Feeney; Marylyn M Addo; Lidia Ruiz; Danni Ramduth; Prakash Jeena; Marcus Altfeld; Stephanie Thomas; Yanhua Tang; Cori L Verrill; Catherine Dixon; Julia G Prado; Photini Kiepiela; Javier Martinez-Picado; Bruce D Walker; Philip J R Goulder
Journal:  J Exp Med       Date:  2004-04-05       Impact factor: 14.307

10.  Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial.

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Journal:  J Exp Med       Date:  2004-06-21       Impact factor: 14.307
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  147 in total

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Authors:  Olusimidele T Akinsiku; Anju Bansal; Steffanie Sabbaj; Sonya L Heath; Paul A Goepfert
Journal:  J Acquir Immune Defic Syndr       Date:  2011-10-01       Impact factor: 3.731

2.  Correlates of spontaneous viral control among long-term survivors of perinatal HIV-1 infection expressing human leukocyte antigen-B57.

Authors:  Yanhua Tang; Sihong Huang; Jacqueline Dunkley-Thompson; Julianne C Steel-Duncan; Elizabeth G Ryland; M Anne St John; Rohan Hazra; Celia D C Christie; Margaret E Feeney
Journal:  AIDS       Date:  2010-06-19       Impact factor: 4.177

3.  Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity.

Authors:  Jaclyn K Wright; Vanessa L Naidoo; Zabrina L Brumme; Jessica L Prince; Daniel T Claiborne; Philip J R Goulder; Mark A Brockman; Eric Hunter; Thumbi Ndung'u
Journal:  J Virol       Date:  2012-01-11       Impact factor: 5.103

4.  Pyrosequencing reveals restricted patterns of CD8+ T cell escape-associated compensatory mutations in simian immunodeficiency virus.

Authors:  Benjamin J Burwitz; Jonah B Sacha; Jason S Reed; Laura P Newman; Francesca A Norante; Benjamin N Bimber; Nancy A Wilson; David I Watkins; David H O'Connor
Journal:  J Virol       Date:  2011-10-12       Impact factor: 5.103

5.  Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus.

Authors:  Karen A O'Connell; Timothy P Brennan; Justin R Bailey; Stuart C Ray; Robert F Siliciano; Joel N Blankson
Journal:  J Virol       Date:  2010-05-05       Impact factor: 5.103

6.  Constraints on HIV-1 diversity from protein structure.

Authors:  Jeongmin Woo; David L Robertson; Simon C Lovell
Journal:  J Virol       Date:  2010-09-29       Impact factor: 5.103

7.  CD8+ T cell escape mutations in simian immunodeficiency virus SIVmac239 cause fitness defects in vivo, and many revert after transmission.

Authors:  Philip A Mudd; Adam J Ericsen; Andrew D Walsh; Enrique J León; Nancy A Wilson; Nicholas J Maness; Thomas C Friedrich; David I Watkins
Journal:  J Virol       Date:  2011-09-28       Impact factor: 5.103

8.  Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations.

Authors:  Christoph Neumann-Haefelin; Cesar Oniangue-Ndza; Thomas Kuntzen; Julia Schmidt; Katja Nitschke; John Sidney; Célia Caillet-Saguy; Marco Binder; Nadine Kersting; Michael W Kemper; Karen A Power; Susan Ingber; Laura L Reyor; Kelsey Hills-Evans; Arthur Y Kim; Georg M Lauer; Volker Lohmann; Alessandro Sette; Matthew R Henn; Stéphane Bressanelli; Robert Thimme; Todd M Allen
Journal:  Hepatology       Date:  2011-10       Impact factor: 17.425

9.  Impact of HLA-B*52:01-Driven Escape Mutations on Viral Replicative Capacity.

Authors:  Ming-Han Chloe Tsai; Supriya Singh; Emily Adland; Philip Goulder
Journal:  J Virol       Date:  2020-06-16       Impact factor: 5.103

10.  CD8+ TCR Bias and Immunodominance in HIV-1 Infection.

Authors:  Henrik N Kløverpris; Reuben McGregor; James E McLaren; Kristin Ladell; Mikkel Harndahl; Anette Stryhn; Jonathan M Carlson; Catherine Koofhethile; Bram Gerritsen; Can Keşmir; Fabian Chen; Lynn Riddell; Graz Luzzi; Alasdair Leslie; Bruce D Walker; Thumbi Ndung'u; Søren Buus; David A Price; Philip J Goulder
Journal:  J Immunol       Date:  2015-04-24       Impact factor: 5.422
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