| Literature DB >> 17507232 |
Rubén Córdoba1, Nélida Salvador Tormo, Antonio Fernández Medarde, Joaquín Plumet.
Abstract
A series of analogues of the potentially angiogenic inhibitor aeroplysinin-1 1 were synthesized and their in vitro antiangiogenic and cytotoxic activities evaluated. In the case of epoxy ketone 6 and azlactone 36 the relationship sprouting inhibition assay/cytotoxicity in BAE cells was enhanced by one order and two orders of magnitude, respectively, with respect to the reference. These results imply more specific antiangiogenic properties for the synthesized derivatives.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17507232 DOI： 10.1016/j.bmc.2007.05.011
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641