Literature DB >> 17507220

Synthesis and preliminary evaluation of mono-[123I]iodohypericin monocarboxylic acid as a necrosis avid imaging agent.

Humphrey Fonge1, Lixin Jin, Huaijun Wang, Yicheng Ni, Guy Bormans, Alfons Verbruggen.   

Abstract

Hypericin monocarboxylic acid was synthesized in an overall yield of 25% in four steps and radiolabelled with iodine-123 in good yield (>75%). The resulting mono-[(123)I]iodohypericin monocarboxylic acid was evaluated in normal mice and in rats with ethanol induced liver necrosis. In this model, tracer concentration in necrotic liver tissue was 14 times higher than in the viable liver tissue as quantified by autoradiography at 24h post injection. The results indicate the feasibility of visualization of necrotic tissue with the novel tracer.

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Year:  2007        PMID： 17507220     DOI： 10.1016/j.bmcl.2007.04.083

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

Review 1.  An overview on development and application of an experimental platform for quantitative cardiac imaging research in rabbit models of myocardial infarction.

Authors:  Yuanbo Feng; Jan Bogaert; Raymond Oyen; Yicheng Ni
Journal:  Quant Imaging Med Surg       Date:  2014-10

2.  Binding and "pKa" modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein.

Authors:  Robert W Haushalter; Fabian V Filipp; Kwang-Seuk Ko; Ricky Yu; Stanley J Opella; Michael D Burkart
Journal:  ACS Chem Biol       Date:  2011-02-22       Impact factor: 5.100

3.  Effects of Glycosylation on Biodistribution and Imaging Quality of Necrotic Myocardium of Iodine-131-Labeled Sennidins.

Authors:  Ling Li; Dongjian Zhang; Shengwei Yang; Shaoli Song; Jindian Li; Qin Wang; Cong Wang; Yuanbo Feng; Yicheng Ni; Jian Zhang; Wei Liu; Zhiqi Yin
Journal:  Mol Imaging Biol       Date:  2016-12       Impact factor: 3.488

4.  Biliary and duodenal drainage for reducing the radiotoxic risk of antineoplastic 131I-hypericin in rat models.

Authors:  Yue Li; Cuihua Jiang; Xiao Jiang; Ziping Sun; Marlein Miranda Cona; Wei Liu; Jian Zhang; Yicheng Ni
Journal:  Exp Biol Med (Maywood)       Date:  2015-05-07

Review 5.  A review on various targeted anticancer therapies.

Authors:  Junjie Li; Feng Chen; Marlein Miranda Cona; Yuanbo Feng; Uwe Himmelreich; Raymond Oyen; Alfons Verbruggen; Yicheng Ni
Journal:  Target Oncol       Date:  2012-02-15       Impact factor: 4.493

Review 6.  Biomarkers and molecular probes for cell death imaging and targeted therapeutics.

Authors:  Bryan A Smith; Bradley D Smith
Journal:  Bioconjug Chem       Date:  2012-09-26       Impact factor: 4.774

7.  Small Molecule Sequential Dual-Targeting Theragnostic Strategy (SMSDTTS): from Preclinical Experiments towards Possible Clinical Anticancer Applications.

Authors:  Junjie Li; Raymond Oyen; Alfons Verbruggen; Yicheng Ni
Journal:  J Cancer       Date:  2013-01-22       Impact factor: 4.207

Review 8.  Necrosis avidity: a newly discovered feature of hypericin and its preclinical applications in necrosis imaging.

Authors:  Binghu Jiang; Jichen Wang; Yicheng Ni; Feng Chen
Journal:  Theranostics       Date:  2013-08-10       Impact factor: 11.556
  8 in total

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