Literature DB >> 1750682

Analysis of cardiolipin molecular species by high-performance liquid chromatography of its derivative 1,3-bisphosphatidyl-2-benzoyl-sn-glycerol dimethyl ester.

M Schlame1, D Otten.   

Abstract

Cardiolipin (CL, 1,3-bisphosphatidyl-sn-glycerol) is a four-acyl-chain phospholipid whose molecular species composition cannot be analyzed by standard procedures. Here we report a method to resolve the molecular species of CL by high-performance liquid chromatography of its derivative 1,3-bisphosphatidyl-2-benzoyl-sn-glycerol dimethyl ester. The CL derivative was characterized by 1H nuclear magnetic resonance spectroscopy, ultraviolet (uv) spectroscopy, thin-layer chromatography, and fatty acid analysis. The derivatization procedure did not change the fatty acid profile and provided a virtually complete conversion to the highly apolar, uv-visible product. In HPLC separations, recorded by 228 nm absorbance, a linear correlation was found between the area of individual peaks and their amount of lipid phosphorus. Bovine heart CL was resolved into 11 molecular species of which 6 (together accounting for 97 mol%) could be identified. The molecular species of bovine heart CL feature a linear relationship between their logarithmic retention time and their double bond number.

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Year:  1991        PMID： 1750682     DOI： 10.1016/0003-2697(91)90332-n

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  10 in total

1.  Characterization of cardiolipin as the sodiated ions by positive-ion electrospray ionization with multiple stage quadrupole ion-trap mass spectrometry.

Authors:  Fong-Fu Hsu; John Turk
Journal:  J Am Soc Mass Spectrom       Date:  2006-06-05       Impact factor: 3.109

2.  Structural characterization of cardiolipin by tandem quadrupole and multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization.

Authors:  Fong-Fu Hsu; John Turk; Elizabeth R Rhoades; David G Russell; Yixin Shi; Eduardo A Groisman
Journal:  J Am Soc Mass Spectrom       Date:  2005-04       Impact factor: 3.109

3.  Characterization of cardiolipin from Escherichia coli by electrospray ionization with multiple stage quadrupole ion-trap mass spectrometric analysis of [M - 2H + Na]- ions.

Authors:  Fong-Fu Hsu; John Turk
Journal:  J Am Soc Mass Spectrom       Date:  2006-01-25       Impact factor: 3.109

4.  Dietary fatty acids modulate liver mitochondrial cardiolipin content and its fatty acid composition in rats with non alcoholic fatty liver disease.

Authors:  Manar Aoun; Gilles Fouret; Françoise Michel; Béatrice Bonafos; Jeanne Ramos; Jean-Paul Cristol; Marie-Annette Carbonneau; Charles Coudray; Christine Feillet-Coudray
Journal:  J Bioenerg Biomembr       Date:  2012-06-12       Impact factor: 2.945

Review 5.  The role of cardiolipin concentration and acyl chain composition on mitochondrial inner membrane molecular organization and function.

Authors:  Edward Ross Pennington; Katsuhiko Funai; David A Brown; Saame Raza Shaikh
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2019-04-02       Impact factor: 4.698

6.  Toward total structural analysis of cardiolipins: multiple-stage linear ion-trap mass spectrometry on the [M - 2H + 3Li]+ ions.

Authors:  Fong-Fu Hsu; John Turk
Journal:  J Am Soc Mass Spectrom       Date:  2010-08-07       Impact factor: 3.109

7.  Linoleate-rich high-fat diet decreases mortality in hypertensive heart failure rats compared with lard and low-fat diets.

Authors:  Adam J Chicco; Genevieve C Sparagna; Sylvia A McCune; Christopher A Johnson; Robert C Murphy; David A Bolden; Meredith L Rees; Ryan T Gardner; Russell L Moore
Journal:  Hypertension       Date:  2008-07-28       Impact factor: 10.190

8.  Effects of various dietary fats on cardiolipin acyl composition during ontogeny of mice.

Authors:  A Berger; M E Gershwin; J B German
Journal:  Lipids       Date:  1992-08       Impact factor: 1.880

9.  Dietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins.

Authors:  Irina G Stavrovskaya; Susan S Bird; Vasant R Marur; Matthew J Sniatynski; Sergei V Baranov; Heather K Greenberg; Caryn L Porter; Bruce S Kristal
Journal:  J Lipid Res       Date:  2013-05-20       Impact factor: 5.922

Review 10.  Disorders of phospholipid metabolism: an emerging class of mitochondrial disease due to defects in nuclear genes.

Authors:  Ya-Wen Lu; Steven M Claypool
Journal:  Front Genet       Date:  2015-02-03       Impact factor: 4.599
  10 in total

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