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Literature DB >> 17505778

Unexpected case of aplastic anemia in a patient with glioblastoma multiforme treated with Temozolomide.

Rakesh Jalali¹, Pritanjali Singh, Hari Menon, Sumeet Gujral.

Abstract

We report the case of a 30-year-old woman with glioblastoma multiforme (GBM) treated with surgery followed by concomitant Temozolomide (TMZ) and external beam radiation, which she tolerated well without any interruptions. However, when she was being evaluated for adjuvant Temozolomide, she developed progressive decline in leukocyte counts and platelet counts and subsequently, febrile neutropenia with bleeding manifestations. A bone marrow aspiration and biopsy done showed a gross hypocellular bone marrow with very few erythriod and myeloid cells and no suggestion of progenitor cells, consistent with aplastic anemia.

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Year: 2007 PMID： 17505778 DOI： 10.1007/s11060-007-9398-z

Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130

7 in total

1. Aplastic anaemia in patient with glioblastoma multiforme treated with temozolomide.

Authors: J Lee Villano; Cindy A Collins; Elisabet E Manasanch; Charulata Ramaprasad; Koen van Besien
Journal: Lancet Oncol Date: 2006-05 Impact factor: 41.316

Review 2. Treatment-related myelodysplasia/AML in a patient with a history of breast cancer and an oligodendroglioma treated with temozolomide: case study and review of the literature.

Authors: Vanita Noronha; Nancy Berliner; Karen K Ballen; Jill Lacy; Jean Kracher; Joachim Baehring; John W Henson
Journal: Neuro Oncol Date: 2006-05-25 Impact factor: 12.300

3. The impact of Asian descent on the incidence of acquired severe aplastic anaemia in children.

Authors: Emma McCahon; Keith Tang; Paul C J Rogers; Mary L McBride; Kirk R Schultz
Journal: Br J Haematol Date: 2003-04 Impact factor: 6.998

Review 4. Aplastic anaemia.

Authors: Robert A Brodsky; Richard J Jones
Journal: Lancet Date: 2005 May 7-13 Impact factor: 79.321

Review 5. Current and future developments in the use of temozolomide for the treatment of brain tumours.

Authors: R Stupp; M Gander; S Leyvraz; E Newlands
Journal: Lancet Oncol Date: 2001-09 Impact factor: 41.316

6. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.

Authors: Roger Stupp; Warren P Mason; Martin J van den Bent; Michael Weller; Barbara Fisher; Martin J B Taphoorn; Karl Belanger; Alba A Brandes; Christine Marosi; Ulrich Bogdahn; Jürgen Curschmann; Robert C Janzer; Samuel K Ludwin; Thierry Gorlia; Anouk Allgeier; Denis Lacombe; J Gregory Cairncross; Elizabeth Eisenhauer; René O Mirimanoff
Journal: N Engl J Med Date: 2005-03-10 Impact factor: 91.245

7. An association of aplastic anaemia in Thailand with low socioeconomic status. Aplastic Anemia Study Group.

Authors: S Issaragrisil; D W Kaufman; T E Anderson; K Chansung; T Thamprasit; J Sirijirachai; A Piankijagum; Y Porapakham; S Vannasaeng; P E Leaverton
Journal: Br J Haematol Date: 1995-09 Impact factor: 6.998

7 in total

12 in total

1. Haematological toxicity of Valproic acid compared to Levetiracetam in patients with glioblastoma multiforme undergoing concomitant radio-chemotherapy: a retrospective cohort study.

Authors: Alexander Tinchon; Stefan Oberndorfer; Christine Marosi; Andreas Gleiss; Angelika Geroldinger; Cornelia Sax; Camillo Sherif; Walter Moser; Wolfgang Grisold
Journal: J Neurol Date: 2014-10-31 Impact factor: 4.849

2. Aplastic anemia with concurrent temozolomide treatment in a patient with glioblastoma multiforme.

Authors: J Oh; G J Kutas; P Davey; M Morrison; J R Perry
Journal: Curr Oncol Date: 2010-08 Impact factor: 3.677

3. Temozolomide-induced aplastic anaemia and incidental low-grade B-cell non-Hodgkin lymphoma in a geriatric patient with glioblastoma multiforme.

Authors: Felipe Batalini; Matthew R Kaufmann; Gabriel Francisco Aleixo; Reed Drews
Journal: BMJ Case Rep Date: 2019-06-29

4. Characterization and prognosis of temozolomide-induced aplastic anemia in patients with central nervous system malignancies.

Authors: Albert K Park; Anem Waheed; Deborah A Forst; Hanny Al-Samkari
Journal: Neuro Oncol Date: 2022-06-01 Impact factor: 13.029

5. Risk analysis of severe myelotoxicity with temozolomide: the effects of clinical and genetic factors.

Authors: Terri S Armstrong; Yumei Cao; Michael E Scheurer; Elizabeth Vera-Bolaños; Rochelle Manning; Mehmet F Okcu; Melissa Bondy; Renke Zhou; Mark R Gilbert
Journal: Neuro Oncol Date: 2009-12 Impact factor: 12.300

6. Bone marrow transplantation for severe aplastic anemia secondary to temozolomide.

Authors: E Brannon Morris; Kimberly Kasow; Ulrike Reiss; David Ellison; Alberto Broniscer
Journal: J Neurooncol Date: 2008-09-26 Impact factor: 4.130

7. Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly diagnosed glioblastoma--analysis of O6-methylguanine-DNA methyltransferase status.

Authors: Motoo Nagane; Kyoko Nozue; Saki Shimizu; Andreas Waha; Hiroshi Miyazaki; Hiroki Kurita; Masashi Homori; Yasunori Fujioka; Yoshiaki Shiokawa
Journal: J Neurooncol Date: 2008-11-27 Impact factor: 4.130